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This paper is concerned with exploring the microscopic basis for the discrete versions of the standard replicator equation and the adjusted replicator equation. To this end, we introduce frequency-dependent selection-as a result of competition fashioned by game-theoretic consideration-into the Wright-Fisher process, a stochastic birth-death process. The process is further considered to be active in a generation-wise nonoverlapping finite population where individuals play a two-strategy bimatrix population game. Subsequently, connections among the corresponding master equation, the Fokker-Planck equation, and the Langevin equation are exploited to arrive at the deterministic discrete replicator maps in the limit of infinite population size.
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http://dx.doi.org/10.1063/5.0032311 | DOI Listing |
J Theor Biol
September 2025
Guangdong Immune Cell Therapy Engineering and Technology Research Center, Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address:
Chimeric antigen receptor (CAR)-macrophage therapy is a promising approach for tumour treatment due to antigen-specific phagocytosis and tumour clearance. However, the precise impact of tumour burden, dose and dosing regimens on therapeutic outcomes remains poorly understood. We developed ordinary differential equation (ODE) mathematical modelling and utilised parameter inference to analyse in vitro FACS-based phagocytosis assay data testing CD19-positive Raji tumour cell against CAR-macrophage, and revealed that phagocytosing efficiency of CAR-macrophage increases but saturates as both Raji cell and CAR-macrophage concentrations increase.
View Article and Find Full Text PDFJ Assoc Res Otolaryngol
September 2025
Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Purpose: The mammalian cochlea has two types of low abundance and highly specialized inner (IHC) and outer (OHC) mechanosensory hair cells. Their malfunction or death is a common cause of congenital and acquired deafness. IHCs and OHCs exhibit different transcriptomes during development.
View Article and Find Full Text PDFAsian Nurs Res (Korean Soc Nurs Sci)
September 2025
Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address:
Purpose: Diabetes has the most detrimental impact on the dietary freedom of people with type 2 diabetes (T2D), and it is important to facilitate dietary self-care behaviors in people with T2D without impairing quality of life (QOL). Autonomous motivation to perform dietary self-care behaviors could lessen their psychological burden and maintain their QOL. Therefore, the purpose of the study was to identify the relationship between autonomous motivation for dietary self-care behaviors and QOL in people with T2D by establishing a hypothetical model using competence and implementation levels of dietary self-care behaviors as mediating variables.
View Article and Find Full Text PDFChaos
September 2025
Department of Information Physics and Computing, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
The increasing energy consumption required for information processing has become a significant challenge, leading to growing interest in optical and optoelectronic reservoir computing as a more efficient alternative. Trained reservoir computers are especially suited for low-energy applications near the edge. However, the computational cost of training the reservoir output weights, particularly due to matrix operations, adds potentially unwanted complexity to the architecture.
View Article and Find Full Text PDFSmall
September 2025
Institute of High Pressure Physics, School of Physical Science and Technology, Ningbo University, Ningbo, 315211, China.
Fundamentally understanding lattice dynamics and thermal transport behavior in liquid-like, partially occupied compounds remains a long-standing challenge in condensed matter physics. Here, the microscopic mechanisms are investigated underlying the ultralow thermal conductivity in ordered/liquid-like CuBiS by combining experimental methods with first-principles calculations. The ordered structure and liquid-like are first experimentally synthesized and characterized, partially Cu-atom occupied CuBiS structure with increasing temperature.
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