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http://dx.doi.org/10.1016/j.bja.2021.01.025 | DOI Listing |
Acad Psychiatry
September 2025
University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Traffic Inj Prev
September 2025
School of Transportation and Vehicle Engineering, Shandong University of Technology, Zibo, China.
Objective: Urban short underpass tunnels, characterized by steep longitudinal slopes, limited lengths, and abrupt light transitions, pose significant driving risks. This study aims to comprehensively investigate drivers' speed control behavior, visual adaptation processes, and mental workload mechanisms within such tunnels under real traffic conditions.
Methods: A real-vehicle experiment was conducted involving 35 drivers.
Phys Chem Chem Phys
September 2025
Department of Physical Chemistry, University of Chemistry and Technology, Technická 5, 16628 Prague, Czech Republic.
In living organisms, proteins and peptides are often under the influence of mechanical forces, especially in confined spaces such as membrane channels, the ribosome exit tunnel, or the proteasome gate. Due to the directional nature of proteins as polymers with distinct ends, forces have the potential to influence protein conformational dynamics in a direction-dependent manner. In this study, we employed force-probe molecular dynamics simulations to investigate the impact of pulling a peptide through a confined environment pushing it in the same direction.
View Article and Find Full Text PDFJ Med Chem
September 2025
Center for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, New Jersey 08854, United States.
Dengue viruses (DENVs) infect approximately 400 million people each year, and currently, there are no effective therapeutics available. To explore potential starting points for antiviral drug development, we conducted a large-scale crystallographic fragment screen targeting the RNA-dependent RNA polymerase (RdRp) domain of the nonstructural protein 5 (NS5) from DENV serotype 2. Our screening, which involved 1108 fragments, identified 60 hit compounds across various known binding sites, including the active site, N pocket, and RNA tunnel.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
State Key Laboratory of Water Pollution Control and Green Resource Recycling, School of the Environment, Nanjing University, Nanjing, China; Institute for the Environment and Health, Nanjing University Suzhou Campus, Suzhou, China. Electronic address:
The in-situ utilization of dissolved organic matter (DOM) for photosensitized activation of chemical oxidants towards micropollutant abatement presents a promising strategy aligned with the UN's Sustainable Development Goals. This study investigates the degradation of micropollutants via DOM-mediated photosensitized activation of peracetic acid (PAA) under solar irradiation and elucidates the underlying mechanisms. In wastewater effluent containing 5 mg/L DOM and 83 μM PAA, sunlight exposure facilitated DOM-mediated PAA activation, increasing the concentration of oxidative reactive species (ORS) by 50 % compared to DOM-free conditions.
View Article and Find Full Text PDF