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Context: Adolescent female athletes are at risk for menstrual dysfunction in the setting of exercise and low energy availability. Education regarding menstrual dysfunction and its associated consequences is important to promote athlete wellbeing.
Objective: The primary aim was to determine the prevalence and characteristics of female athletes who believed that losing their period was a normal response to high training demands. The secondary aim was to explore the relationship between menstrual dysfunction and patient-reported quality of life measures.
Design: Cross-sectional study.
Setting: Preparticipation evaluations for a local high school district.
Patients Or Other Participants: Female athletes, 13-18 years old (n = 90).
Main Outcome Measure(s): Health history, family affluence, and patient-reported quality of life measures.
Results: Forty four percent (n = 40) of 90 adolescent athletes answered that losing their period was a normal response to a high level of training, and this group had a lower body mass index, were less likely to report being worried about their current weight, and had a higher family affluence level than those who answered that losing their period was not a normal response to training. The overall prevalence of menstrual dysfunction was 28%. After adjusting for age and body mass index, we found that menstrual dysfunction was significantly associated with higher levels of anxiety, fatigue, and pain interference.
Conclusions: Nearly half of our sample of adolescent female athletes perceived losing their period was a normal response to high training demands. Females with menstrual dysfunction reported higher levels of anxiety, fatigue, and pain interference than those without menstrual dysfunction. Understanding adolescent perceptions of menstrual dysfunction and the characteristics of those with menstrual dysfunction can guide the development of future educational interventions aimed at athletes at risk for the female athlete triad.
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http://dx.doi.org/10.4085/624-20 | DOI Listing |
Pediatr Ann
September 2025
Pediatric Gynecology Program, Children's National Hospital, Washington, DC.
Abnormal uterine bleeding (AUB), a common gynecologic concern in adolescents, often leads to significant physical and emotional distress. This article provides a comprehensive overview of AUB in adolescence, including classification, common causes, diagnosis, and management. The physiology of the hypothalamic-pituitary-ovarian axis is reviewed, highlighting its role in menstrual regulation and the immaturity-related anovulation that commonly contributes to AUB in the first 2 to 3 years after menarche.
View Article and Find Full Text PDFPediatr Allergy Immunol
September 2025
Allergy Department, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Cofactors are external factors that can lower the threshold dose of an allergen and amplify the severity of allergic reactions, turning mild or moderate responses into severe anaphylaxis. These include exercise, nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, menstruation, and infections. Initially described in relation to food allergens and physical activity or NSAIDs, these reactions have been labeled under various terms, such as food-dependent exercise-induced anaphylaxis (FDEIA), wheat-dependent exercise-induced anaphylaxis (WDEIA), and food-dependent NSAID-induced anaphylaxis (FDNIA).
View Article and Find Full Text PDFMol Biol Rep
September 2025
Faculty of Medicine, Department of Histology and Embryology, Mugla Sitki Kocman University, Mugla, Türkiye.
As a gynecological disease, endometriosis is a disease in which pain and inflammation are important parts. Endometriosis is a chronic, estrogen-related situation with a multifactorial etiology that remains incompletely understood. Endometriosis affects approximately 6-10% of females and is a prominent reason of infertility.
View Article and Find Full Text PDFFront Psychol
August 2025
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Introduction: School bullying poses significant risks to the physiological and psychological health of female adolescent migrants, a vulnerable group often overlooked during their critical developmental period. This study investigates the specific correlations between different types of bullying exposure and multi-dimensional health outcomes among female high school students aged 15 to 18 in China.
Methods: Data were derived from a longitudinal observational cohort, including clinical records and structured survey assessments.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Physiology, Women Medical College, Abbottabad, Pakistan.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age characterized by metabolic dysfunction, insulin resistance, and hormonal imbalance. Metformin, a well-known insulin sensitizer, and Resveratrol, an antioxidant polyphenol, have both shown promise in managing the metabolic and reproductive features of PCOS. This study evaluates the effects of Resveratrol alone and in combination with Metformin on clinical, metabolic, endocrine and reproductive parameters in women with PCOS over a 6-month period.
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