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The promise of quantum computing lies in harnessing programmable quantum devices for practical applications such as efficient simulation of quantum materials and condensed matter systems. One important task is the simulation of geometrically frustrated magnets in which topological phenomena can emerge from competition between quantum and thermal fluctuations. Here we report on experimental observations of equilibration in such simulations, measured on up to 1440 qubits with microsecond resolution. By initializing the system in a state with topological obstruction, we observe quantum annealing (QA) equilibration timescales in excess of one microsecond. Measurements indicate a dynamical advantage in the quantum simulation compared with spatially local update dynamics of path-integral Monte Carlo (PIMC). The advantage increases with both system size and inverse temperature, exceeding a million-fold speedup over an efficient CPU implementation. PIMC is a leading classical method for such simulations, and a scaling advantage of this type was recently shown to be impossible in certain restricted settings. This is therefore an important piece of experimental evidence that PIMC does not simulate QA dynamics even for sign-problem-free Hamiltonians, and that near-term quantum devices can be used to accelerate computational tasks of practical relevance.
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http://dx.doi.org/10.1038/s41467-021-20901-5 | DOI Listing |
Food Chem
September 2025
International Joint Research Laboratory for Biointerface and Biodetection, and School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, PR China. Electronic address:
Mycotoxins, due to their high carcinogenic and genotoxic properties, pose a significant threat to global food safety. Traditional detection methods often fall short in meeting the demands for large-scale, real-time, simple, and rapid monitoring. As a result, innovative rapid detection approaches, leveraging advanced materials and sensor technologies, are emerging as key solutions for preventing food contamination.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
The Biorobotics Institute, Scuola Superiore Sant'Anna, Pisa 56025, Italy.
Aquatic microorganisms typically inhabit a heterogeneous resource landscape, composed of localized and transient patches. To effectively exploit these resources, they have evolved a wide range of feeding strategies that combine chemotactic motility with active feeding flows. However, there is a notable lack of experimental studies that examine how these active flows shape resource fields to optimize feeding.
View Article and Find Full Text PDFPLoS One
September 2025
School of Medical Engineering, Xinxiang Medical University, Xinxiang, China.
Computer-aided diagnostic (CAD) systems for color fundus images play a critical role in the early detection of fundus diseases, including diabetes, hypertension, and cerebrovascular disorders. Although deep learning has substantially advanced automatic segmentation techniques in this field, several challenges persist, such as limited labeled datasets, significant structural variations in blood vessels, and persistent dataset discrepancies, which continue to hinder progress. These challenges lead to inconsistent segmentation performance, particularly for small vessels and branch regions.
View Article and Find Full Text PDFInt Urogynecol J
September 2025
Department of Gynecology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), Foshan, 528308, PR China.
Introduction And Hypothesis: This study aimed to evaluate the effectiveness of platelet-rich plasma (PRP) combined with fractional CO laser therapy in women diagnosed with mild or moderate stress urinary incontinence (SUI).
Methods: In this single-center, single-blinded, randomized controlled trial, 69 women diagnosed with mild or moderate SUI were randomly assigned to receive fractional CO laser therapy, PRP injections, or a combination of both treatments (n = 23 per group). Each participant underwent three treatment sessions at 30-day intervals.
J Chem Phys
September 2025
School of Materials, Sun Yat-Sen University, Shenzhen, Guangdong 518107, China.
We introduce an extended formulation of the non-Markovian stochastic Schrödinger equation with complex frequency modes (extended cNMSSE), designed for simulating open quantum system dynamics under arbitrary spectral densities. This extension employs non-exponential basis sets to expand the bath correlation functions, overcoming the reliance of the original cNMSSE on exponential decompositions of the spectral density. Consequently, the extended cNMSSE is applicable to environments beyond those characterized by Debye-type spectral densities.
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