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Present research work discloses new and novel synthesis of metal complexes (Fe, Cu, Zn, Sb and Sn) of 3, 4, 5-trihydroxybenzoic acid derivative containing aniline moiety with substitution at C-7 position of 3, 4, 5-trihydroxybenzoic acid in order to enhance its biological activities by coupling therapeutic values of transition metals as well. In vitro antibacterial and antifungal activities of these compounds has been performed by using agar diffusion method against different bacterial and fungal strains. The free radical scavenging assay was performed by using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH). Cytotoxic action of compounds was assessed by utilizing the standard MTT (3-[4, 5-dimethylthiazole-2-yl]-2, 5-diphenyl-tetrazolium bromide) colorimetric assay. The structure of newly synthesized complexes were confirmed by using IR and HNMR spectral analysis.
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Front Pharmacol
June 2025
Doctor of Osteopathic Medicine Program, Philadelphia College of Osteopathic Medicine - Georgia Campus, Suwanee, GA, United States.
Natural compounds have emerged as promising therapeutic agents for treating cancers such as multiple myeloma (MM). However, poor bioavailability, low stability, and suboptimal targeting often limit their clinical efficacy. Recent advances in nanotechnology have addressed these limitations by utilizing nanoparticle (NP) carriers to enhance the therapeutic potential of natural compounds through improved solubility, stability, and selective delivery to cancer cells.
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September 2025
State Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; National Center of Technology Innovation for Synthetic Biology, Tianjin, 300308, China. Electronic address:
Gallic acid (GA), a natural phenolic acid antioxidant, has significant therapeutic and industrial applications. However, its traditional manufacturing approach, based on plant extraction, has been associated with risks of environmental pollution as well as a limited range of applications. Consequently, microbial-based production of GA, being more environmental-friendly, is viewed as a potential alternative.
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October 2024
Institute of Postharvest and Food Sciences, Agricultural Research Organization, The Volcani Institute, 68 HaMaccabim Road, P.O. Box 15159, Rishon LeZion 7505101, Israel.
The purpose of the present study was to investigate the mechanism of action of our newly developed green sanitizer formulation comprising a natural phenolic compound, gallic acid (GA), strengthened by the Generally Recognized as Safe (GRAS) materials hydrogen peroxide (HO) and DL-lactic acid (LA). Combining 8 mM GA with 1 mM HO resulted in an abundant generation of reactive oxygen species (ROS) and a bactericidal effect towards Gram-negative (, , and ) and Gram-positive () bacteria (4 to 8 log CFU mL reduction). However, the exposure to this dual formulation (DF) caused only a modest 0.
View Article and Find Full Text PDFInt J Biol Macromol
November 2024
School of Food Science and Engineering, Hainan University, Haikou 570228, PR China; Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Hainan University, Haikou 570228, PR China. Electronic address:
Enzyme Microb Technol
October 2024
Department of Biosciences, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-machi, Tsuruoka 997-8555, Japan. Electronic address:
Paraben hydrolase and tannase catalyze the hydrolysis of parabens (4-hydroxybenzoic acid esters) and gallic acid (3,4,5-trihydroxybenzoic acid) esters, respectively. Paraben hydrolase (AoPrbA) and tannase (AoTanB) from Aspergillus oryzae belong to the tannase family in the ESTHER database. However, the substrate specificities of AoPrbA and AoTanB are narrow.
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