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Previous work has shown that it is possible to use a mechanical phase variable to accurately quantify the progression through a human gait cycle, even in the presence of disturbances. However, mechanical phase variables are highly dependent on the behavior of the body segment from which they are measured, which can change with the human's task or in response to different disturbances. In this study, we compare kinematic parameterization methods based on time, thigh phase angle, and tibia phase angle with motion capture data obtained from ten able-bodied subjects walking at three inclines while experiencing phase-shifting perturbations from a split-belt instrumented treadmill. The belt, direction, and timings of perturbations were quasi-randomly selected to prevent anticipatory action by the subjects and sample different types of perturbations. Statistical analysis revealed that both phase parameterization methods are superior to time parameterization, with thigh phase angle also being superior to tibia phase angle in most cases.
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http://dx.doi.org/10.1109/TNSRE.2021.3057877 | DOI Listing |
J Comput Neurosci
September 2025
School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072, China.
Transcranial alternating current stimulation (tACS) enables non-invasive modulation of brain activity, holding promise for cognitive research and clinical applications. However, it remains unclear how the spiking activity of cortical neurons is modulated by specific electric field (E-field) distributions. Here, we use a multi-scale computational framework that integrates an anatomically accurate head model with morphologically realistic neuron models to simulate the responses of layer 5 pyramidal cells (L5 PCs) to the E-fields generated by conventional M1-SO tACS.
View Article and Find Full Text PDFBiomacromolecules
September 2025
Division of Pharmacy and Optometry, Manchester Institute of Biotechnology, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, M13 9PL Manchester, U.K.
This study investigates how hydrophobic and hydrophilic modifications at the C-terminus of the base peptide, KFEFEFKFK (KbpK), affect the hydrogel macroscopic properties. By the incorporation of phenylalanine (F, hydrophobic) and lysine (K, hydrophilic) residues, four variants, KbpK-K, KbpK-F, KbpK-KF, and KbpK-FK, were designed and evaluated. pH-concentration phase diagrams and Fourier transform infrared confirmed clear links showing how peptide hydrophobicity and charge influence β-sheet formation and macroscopic phase behavior.
View Article and Find Full Text PDFJB JS Open Access
September 2025
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Background: Lower extremity alignment in knee osteoarthritis (OA) is conventionally assessed using standing radiographs. However, symptoms often manifest during gait. Understanding dynamic alignment during gait may help characterize disease progression and inform treatment strategies.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Orthopaedic Surgery, Kobe Red Cross Hospital, Hyogo, Japan.
This study aims to clarify the dynamic changes in the cervical lordotic angle (CLA) during normal swallowing using an automated motion analysis method. Physiological cervical lordosis is crucial for spinal alignment and musculoskeletal function. While previous studies have noted the relevance of cervical curvature in clinical contexts, its dynamic modulation during swallowing has not been well studied.
View Article and Find Full Text PDFSports Biomech
September 2025
Centre for Interdisciplinary Research in Rehabilitation, Lethbridge-Layton-Mackay Rehabilitation Centre, and the School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada.
The objective of this study was to compare joint angles and spatiotemporal variables between male and female ice hockey players during skating slap shots. Thirty-nine collegiate players (25 men, 14 women) participated. Kinematic data were collected using a Xsens 17-inertial measurement system.
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