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http://dx.doi.org/10.4093/dmj.2020.0289 | DOI Listing |
Front Nutr
August 2025
Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, United States.
Background And Objective: Combining natural compounds with conventional drugs is an emerging strategy to improve the management of type 2 diabetes and its precursor, prediabetes. While metformin effectively lowers blood glucose and improves insulin sensitivity, it may cause side effects or lose efficacy over time. Natural agents, particularly polyphenols, are being explored as adjunct therapies to enhance glycemic control, mitigate adverse effects, and slow disease progression.
View Article and Find Full Text PDFCryobiology
September 2025
Department of Stomatology, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, 519000, Guangdong Province, China. Electronic address:
This study explored the protective effects of metformin on human dental pulp stem cells (hDPSCs) during cryopreservation. hDPSCs were isolated from extracted third molars and treated with varying concentrations of metformin to identify the optimal dose for cryoprotection. Among the tested concentrations, 800 μM was found to effectively reduce reactive oxygen species without compromising cell viability.
View Article and Find Full Text PDFChem Biodivers
August 2025
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.
Leaves of Fagopyrum esculentum Moench were selected for their rich content of phytochemicals, offering potential biological activities. The aqueous residual fraction (AF) exhibited higher extraction yield (17.5%) compared with the other fractions.
View Article and Find Full Text PDFCurr Cardiol Rep
August 2025
Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive Bridgeside Point 1; Room 555, Pittsburgh, PA, 15219, USA.
Purpose Of Review: Metabolic changes can play a critical role in the structural and functional decline of the aging cardiovascular system. In this review, we examine how key metabolic pathways and regulatory mechanisms influence cardiovascular aging, highlighting recent studies into metabolic flexibility, mitochondrial function, nutrient sensing, and energy utilization in the aging heart. Potential metabolic-based interventions to mitigate cardiac aging are also discussed.
View Article and Find Full Text PDFCurr Opin Clin Nutr Metab Care
August 2025
Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR.
Purpose Of Review: Aging population rates are significantly increasing and improved quality of life during aging is a top priority. The decline in skeletal muscle mass and strength is a major concern with aging, as it impairs the ability to perform activities of daily living and significantly diminishes quality of life. Effective strategies to counteract this decline are necessary for supporting longevity and enhancing quality of life in older adults.
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