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Introduction: The Centro de Estudos do Bebé e da Criança in Hospital Dona Estefânia has organized a multidisciplinary model for children under three with suspected autism spectrum disorder, thus implementing the recent guidelines established by the Directorate General for Health. The aim of this study is to describe this model and case series.
Material And Methods: A retrospective descriptive study of observed children with suspected ASD. They were observed according to the model of the Centro de Estudos do Bebé e da Criança and DC:0-5TM classification, between January 2018 and September 2019.
Results: The study included 178 children. The average age at the initial assessment was 27 months. From the total sample, 116 children concluded the diagnostic sessions (axis I): Autism Spectrum Disorder/Early Atypical (36%), Developmental Language Disorder (18%), Other (19%). Factors of axes II, III, IV and V of DC:0-5TM were determinant for clinical diagnosis in 26%.
Discussion: Of 116 children, 36% were diagnosed with Autism Spectrum Disorder. This highlights the diagnostic challenge posed by neurodevelopmental disorders in early infancy. The sample shows that the characteristics of the relationship with the caregiver (axis II), presence of physical conditions (axis III), psycho-social stressors (axis IV) and developmental trajectory (axis V) have a significant clinical impact. In the future, the initial assessment should take place well before the age of 27 months because of the impact on prognosis.
Conclusion: This model is a pioneering approach in Portugal. It promotes a common approach of Child and Adolescent Psychiatry and Neuropediatrics/Developmental Pediatrics in early infancy. Moreover, it increases the diagnostic acuity of Autism Spectrum Disorders and early therapeutic intervention.
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http://dx.doi.org/10.20344/amp.13397 | DOI Listing |
Psychopharmacology (Berl)
September 2025
Instituto de Biología Celular y Neurociencias "Prof. De Robertis" (IBCN), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Rationale: Autism spectrum disorders (ASD) are a group of neurodevelopmental and multifactorial conditions with cognitive manifestations. The valproic acid (VPA) rat model is a well-validated model that successfully reproduces the behavioral and neuroanatomical alterations of ASD. Previous studies found atypical brain connectivity and metabolic patterns in VPA animals: local glucose hypermetabolism in the prefrontal cortex, with no metabolic changes in the hippocampus.
View Article and Find Full Text PDFAm J Med Genet B Neuropsychiatr Genet
September 2025
The Central Lab, the Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD. However, their role in neuroimmune interactions and behavioral outcomes remains poorly understood.
View Article and Find Full Text PDFBackground: Adolescents with autism spectrum disorder (ASD) often experience identity confusion, social difficulties, and internalizing symptoms such as anxiety and depression. Physical activity offers opportunities for peer interaction and teamwork, which may help alleviate negative emotions. This study aims to investigate the pathways through which physical activity influences internalizing problems in adolescents with ASD.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, 130021 Changchun, Jilin, China.
Background: The progressive legalization and widespread use of cannabis has led to its use as a treatment for certain neuropsychiatric disorders. Traditional epidemiological studies suggest that cannabis use has an effect on some neurocognitive aspects. However, it is unclear whether cannabis use is causally related to common neuropsychiatric disorders.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875 Beijing, China.
Background: Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder marked by impaired interactions and restricted interests, the pathophysiology of which is not fully understood. The current study explored the potential therapeutic effects of transcranial direct current stimulation (tDCS) on the neurophysiological aspects of ASD, specifically focusing on the brain's excitatory/inhibitory (E/I) balance and behavioral outcomes, providing scientific guidance for ASD intervention.
Methods: Forty-two children with ASD were randomly divided into either an active tDCS or sham tDCS group.