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Background: Measures of fear of progression or recurrence of illnesses have been criticized for neglecting cross-cultural validity. Therefore, we assessed the psychometric properties of the Spanish version of the Fear of Kidney Failure Questionnaire (FKFQ), to determine whether postdonation fear of kidney failure (FKF) influenced the donors' psychosocial status, and define variables that characterized donors with high FKFQ scores.
Methods: We included 492 participants (211 donors) in a multicenter, 11-year, retrospective, cross-sectional study. Donors were classified with a Latent Class Analysis of the FKFQ-item scores and characterized with a multivariable logistic regression analysis. We calculated the risk ratio based on predicted marginal probabilities.
Results: The Spanish version of the FKFQ showed acceptable psychometric properties. FKF was uncommon among donors, but we detected a small subgroup (n = 21, 9.9%) with high FKF (mean FKFQ score = 14.5, 3.1 SD). Compared with other donors, these donors reported higher anxiety and depression (38% and 29% of potential anxiety and depressive disorders), worse quality of life, and less satisfaction with the donation. Donors with high FKFQ scores were characterized by higher neuroticism combined with postdonation physical symptoms that interfered with daily activities.
Conclusions: The FKFQ was cross-culturally valid, and thus, it may be used to assess the FKF in Spanish-speaking donors. New interventions that promote positive affectivity and evidence-based treatments for worry could be adapted for treating FKF.
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http://dx.doi.org/10.1097/TXD.0000000000001100 | DOI Listing |
Lancet Gastroenterol Hepatol
August 2025
Department of Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Psychogastroenterology encompasses both basic mechanistic research, which identifies psychological mechanisms (eg, fear-learning) that contribute to disorders of gut-brain interaction (DGBIs), and clinical applied research, which evaluates the efficacy of gut-brain behavioural therapies in DGBIs. However, progress in the field is hindered by inadequate communication between these areas, such that mechanistic processes are rarely translated into clinical targets, and interventions are developed with an incomplete understanding of the potential mechanisms by which they work or for whom they work. To bridge this translational gap, we propose the psychobiological model of DGBIs-an integrated and testable model that illustrates how psychological mechanisms central to DGBIs interact with each other and with biological processes along the gut-brain axis.
View Article and Find Full Text PDFCureus
July 2025
Internal Medicine/Nephrology, Victory Medical Care PC, New York, USA.
We report a case of a 63-year-old Hispanic female with hypertension and prediabetes, diagnosed with IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS) in 2023. Despite detailed counseling about immunosuppressive therapy, the patient initially refused treatment due to fear of medication side effects. Over two years without consistent nephrology follow-up, her condition rapidly progressed to nephrotic syndrome and end-stage renal disease (ESRD).
View Article and Find Full Text PDFPsychogeriatrics
September 2025
Shanghai Key Laboratory of Mental Health and Psychological Crisis Intervention (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.
Background: With global ageing trends, the well-being of older adults is a growing concern. Chronic kidney disease (CKD) is a common ailment among older adults, often accompanied by mental distress such as depression and anxiety. This study investigates how family support impacts the comorbidity of depression and anxiety in older adults, comparing healthy individuals with those afflicted by CKD.
View Article and Find Full Text PDFJ Clin Med
July 2025
Department of Anaesthesiology Nursing & Intensive Care, Faculty of Health Sciences, Medical University of Gdansk, Debinki 7, 80-211 Gdańsk, Poland.
: Kidney transplantation from a living donor is considered the most beneficial form of treatment for end-stage renal failure, which, in addition to providing patients with better treatment results, significantly improves their quality of life. Understanding factors that influence the willingness to donate kidneys to strangers is critical in promoting and expanding the living donor pool. When considering the decision to become an altruistic kidney donor, individuals must evaluate multiple factors, including the identity of the recipient and their own perceived level of safety.
View Article and Find Full Text PDFJ Wound Care
August 2025
Gothenburg University Centre for Person-Centred Care (GPCC), Gothenburg, Sweden.
Objective: To investigate the experiences of everyday life of patients with diabetic foot ulcers (DFUs) in Sweden.
Method: Semi-structured interviews were conducted from 2021-2022 with patients with active DFUs. The results were subjected to qualitative content analysis.