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Objectives: The objective of this study was to establish and validate a new scoring system for oral lichen planus (OLP).
Study Design: Forty patients with erosive OLP were scored using a new proposed scoring system and the one suggested by Thongprasom. Statistical analysis was used to calculate inter- and intraexaminer reliability, validity, diagnostic accuracy, and clinical sensitivity for both scores.
Results: Concurrent validity showed a significant strong correlation between pain scale and the new score (r = 0.846) versus Thongprasom's score (r = 0.665). Interexaminer agreement showed a statistically significant agreement with the biopsy results (kappa = 0.74) for the new score, whereas no agreement was evident with Thongprasom's score (kappa = 0.03163). The diagnostic accuracy of the new score was area under the curve = 0.839, whereas the diagnostic accuracy of Thongprasom's score was area under the curve = 0.667. Significant differences in the scores were detected while comparing the clinical sensitivity of both systems.
Conclusions: The new comprehensive scoring system could be a valid, reproducible, and sensitive tool to accurately assess the severity of OLP. In addition, the proposed scoring system is easily taught, is relatively faster to master, and does not require complicated calculations.
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http://dx.doi.org/10.1016/j.oooo.2020.12.016 | DOI Listing |
Turk J Pediatr
September 2025
Department of Pediatric Hematology and Oncology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Background: The expression and clinical correlation of BRAFV600E mutation and programmed cell death-1 ligand 1 (PD-L1) in children with Langerhans cell histiocytosis (LCH) have been reported, but the conclusions of previous studies are inconsistent. In addition, it has been reported that elevated cathepsin S (CTSS) expression is associated with various cancers. However, there is currently no research on the correlation between CTSS and LCH.
View Article and Find Full Text PDFAppl Neuropsychol Adult
September 2025
Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México.
Negative symptoms, depression, and cognitive impairments of the schizophrenia spectrum have been associated with difficulties in daily functioning. Compensatory Cognitive Training (CCT) has shown positive effects on cognition, negative symptoms, and functioning in this population. The main objective of this pilot study was to analyze the effects of CCT on cognition and functioning in a group schizophrenia spectrum outpatients in Mexico.
View Article and Find Full Text PDFRetina
September 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, CH-3010.
Purpose: To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.
Methods: A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores.
J Palliat Care
September 2025
Department of Healthcare Administration and Policy, School of Public Health, University of Nevada, Las Vegas, NV, USA.
ObjectivesRecently, atrial fibrillation (AF) has contributed to an increase in cardiovascular deaths in the U.S. Palliative care (PC) and atrial ablation (AA) procedure can elevate quality of life of high-risk AF patients, who are associated with multiple comorbidities.
View Article and Find Full Text PDFEur J Ophthalmol
September 2025
vEyes NPO, vEyes Lab, Milo, Italy.
PurposeTo introduce, describe and validate a novel, 3D-printed portable slit lamp system integrated with a macro lens-equipped smartphone, providing clinicians with a quick, easy, and effective method for obtaining high-quality clinical images.Materials and MethodsA 3D-printed portable slit lamp was developed, comprising a warm white LED light pen housed in a custom case with a biconvex lens focusing light through a 0.4 mm slit.
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