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T-Cell Immune Surveillance in Allogenic Stem Cell Transplant Recipients: Are Whole Blood-Based Assays Ready to Challenge ELISPOT? | LitMetric

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Article Abstract

We compared the feasibility of 4 cytomegalovirus (CMV)- and -reactive T-cell immunoassay protocols in allogenic stem cell transplant recipients. While enzyme-linked immunospot performed best overall, logistically advantageous whole blood-based assays performed comparably in patients with less severe lymphocytopenia. CMV-induced interferon-gamma responses correlated strongly across all protocols and showed high concordance with serology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7794650PMC
http://dx.doi.org/10.1093/ofid/ofaa547DOI Listing

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