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Purpose: Patients with a history of a bone marrow transplant (BMT) have a higher risk of infectious complications because of an immunocompromised state. It has been shown that giving timely antibiotics in 1 hour or less from presentation to the emergency department (ED) decreases morbidity and mortality in this patient population. We hypothesize that a quality improvement (QI) process, termed BMT Fever, will improve timely administration of antibiotics for this population presenting to the ED.
Methods: This is a QI process designed to improve the administration of antibiotics to BMT patients with a subjective or objective fever presenting to the ED. The percent of patients receiving antibiotics within 1 hour or less was compared pre- and post-intervention.
Results: Upon implementation of the BMT Fever QI process, the percentage of patients with febrile BMT receiving antibiotics within 1 hour or less per fiscal quarter significantly improved from six out of 28 patients (21%) to 147 out of 173 patients (85%), value < .05.
Conclusion: By implementing a QI process that addresses five structural obstacles, we were able to improve our timely administration of antibiotics to patients with febrile BMT presenting to the ED.
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http://dx.doi.org/10.1200/OP.20.00430 | DOI Listing |
PLoS One
September 2025
Department of Information Technology, Uppsala University, Uppsala, Sweden.
For effective treatment of bacterial infections, it is essential to identify the species causing the infection as early as possible. Current methods typically require hours of overnight culturing of a bacterial sample and a larger quantity of cells to function effectively. This study uses one-hour phase-contrast time-lapses of single-cell bacterial growth collected from microfluidic chip traps, also known as a "mother machine".
View Article and Find Full Text PDFKlin Mikrobiol Infekc Lek
June 2025
Clinic of Infectious Diseases, Central Military Hospital, Prague, Czech Republic, e-mail:
Objective: To evaluate the quality of care provided to patients with febrile neutropenia (FN) hospitalized at the Depart-ment of Infectious Diseases, Military University Hospital Prague, as a foundation for improving the management of this condition.
Material And Methods: A retrospective observational analysis of patients diagnosed with the ICD-10 code D70 from 1 January 2015 to 1 June 2023. All evaluated parameters were selected primarily to facilitate the assessment of care quality and compliance with recommended practices.
Cureus
July 2025
Internal Medicine, Kantipur Hospital, Lalitpur, NPL.
Scrub typhus, a common febrile illness in South Asia, can rarely cause life-threatening myocarditis with complete heart block. We report a 43-year-old man presenting with a one-week history of fever, shortness of breath, and abdominal pain. Laboratory findings showed transaminitis, hypoalbuminemia, elevated C-reactive protein, and mild hypokalemia, suggesting an infectious etiology.
View Article and Find Full Text PDFFront Public Health
September 2025
Faculty of Medicine, Hashemite University, Zarqa, Jordan.
Exclusive breastfeeding (EBF) is a crucial public health strategy that reduces infant morbidity and mortality, yet rates remain suboptimal among refugee populations. This study examines breastfeeding practices and determinants of EBF among long-standing Palestinian refugees in Jordan through a cross-sectional survey of 249 mothers at the UNRWA Zarqa Camp Health Center. The prevalence of EBF among infants under 6 months was 38.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Department of Mathematics, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, United States of America.
A biofilm is a community of microorganisms adhered to a surface, bound together by extracellular polymeric substances (EPS). They are ubiquitous in nature and develop on a range of surfaces including living tissue. Biofilms themselves typically do not negatively affect their host, but under certain conditions they can retain pathogenic features and cause a wide range of illnesses including persistent or chronic infections.
View Article and Find Full Text PDF