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Background: Low cardiorespiratory fitness is associated with increased risk of hypertension and atherosclerosis in adults with prehypertension. The purpose of this study was to quantify cardiorespiratory fitness and to examine the utility of supramaximal constant-load verification testing for validating maximal oxygen uptake (VO) attainment in adults with prehypertension.
Methods: Eleven adults (four women) with prehypertension (22.5 ± 2.9 y; body mass index (BMI): 24.6 ± 3.2 kg·m) underwent an incremental exercise test followed 15 min later by a verification test at 105% of maximal work rate on a cycle ergometer.
Results: There was no statistical difference in VO between the incremental (2.23 ± 0.54 L·min) and verification tests (2.28 ± 0.54 L·min; = 0.180). Only three out of eleven participants had a higher VO during the verification when compared with the incremental test. If the verification test had not been conducted, one participant would have been incorrectly classified as having low cardiorespiratory fitness based on incremental test results alone.
Conclusions: Verification testing validates the attainment of VO and can potentially reduce the over-diagnosis of functional impairment (i.e., deconditioning) in adults with prehypertension.
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http://dx.doi.org/10.3390/sports9010009 | DOI Listing |
J Cardiovasc Pharmacol
September 2025
Robert M. Berne Cardiovascular Research Center, and Division of Cardiology, University of Virginia, Charlottesville, Virginia, United States.
Cardiorespiratory fitness (CRF) in heart failure (HF) declines with age. Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging and HF. We aimed to determine the changes in CRF before and after treatment with anakinra, recombinant IL-1 receptor antagonist, in patients with HF stratified according to age below and above 60 years in phase II clinical trials.
View Article and Find Full Text PDFEur J Sport Sci
October 2025
Department of Intervention Research in Exercise Training, German Sport University Cologne, Cologne, Germany.
The concurrent validity of lactate thresholds (LT1, LT2) and between-day reliability data from the rowing-specific heart rate variability (HRV)-based thresholds (HRVT) were examined. Thus, 21 rowers (19.6 ± 2.
View Article and Find Full Text PDFBiogerontology
September 2025
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Ashwagandha (Withania somnifera), a revered herb in Ayurvedic medicine, has gained significant scientific recognition for its potential to promote healthy aging. Traditionally used as a Rasayana or rejuvenator, this potent adaptogen helps the body manage stress and enhance vitality. This review synthesises extensive evidence for its multifaceted anti-aging capabilities, which target key hallmarks of the aging process.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Sports Science and Clinical Biomechanics, Sport and Health Sciences Cluster (SHSC), Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Background: Global reports indicate that less than 20% of 11-17-year-olds meet physical activity recommendations, and while organized sports participation increases the likelihood of meeting these guidelines, no other studies were found that examined the impact on well-being and physical fitness outcomes among Danish adolescents based on participation in leisure time sports.
Methods: The study employed a cross-sectional design, assessing cardiorespiratory fitness, fat percentage, and well-being, as well as several other health and fitness outcomes among 1,333 Danish adolescents (50% girls). Differences between participants in organized sports and non-participants, as well as between participants in different sport categories were assessed through ANCOVA analysis.
Curr Cardiol Rep
September 2025
Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ, USA.
Purpose Of Review: VO₂ max is a fundamental marker of cardiorespiratory fitness with substantial prognostic and diagnostic value within the field of cardiology. This review analyzes current and emerging evidence regarding its clinical uses, highlights key evidence gaps, and explores emerging developments poised to broaden its clinical application.
Recent Findings: Evidence supports VO2 max as a powerful independent predictor for heart failure, coronary artery disease, hypertrophic cardiomyopathy, and cardiac amyloidosis, supporting it use in identifying high-risk patients for advanced interventions.