98%
921
2 minutes
20
A 21-year-old man with chief complaints of left hypochondriac and chest pain was shown to have multiple masses in the lung, a pleural effusion in the right cavum thoracis, a mediastinal mass, and lymphadenopathy detected by computed tomographic scan. He was diagnosed with an extragonadal germ cell tumor based on pathologic findings from lung biopsies and elevation of the serum total human chorionic gonadotropin. He underwent a reduced chemotherapy regimen consisting of bleomycin, cisplatin, and etoposide (reduced BEP) to lower the risk of acute respiratory distress syndrome (ARDS), a manifestation of choriocarcinoma syndrome, which occurs at induction chemotherapy with the full-dose BEP regimen. Choriocarcinoma syndrome did not develop during chemotherapy, and he has been disease-free since salvage chemotherapy and subsequent retroperitoneal lymph node dissection.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.14989/ActaUrolJap_66_12_449 | DOI Listing |
Case Rep Pediatr
August 2025
Division of Paediatric Surgical Oncology, Department of Surgical Oncology, Tata Memorial Hospital and Advanced Centre for Training Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India.
Up to one-third of germ cell tumors are extragonadal neoplasms, with yolk sac tumors (YSTs) being the most common malignant histology. This report describes the successful multimodal management of a primary YST of the stomach in a 2-year-old boy. The child presented with melena, and further evaluation revealed a mass lesion in the cardia of the stomach.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjajaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Introduction And Importance: Yolk sac tumor (YST) is a rare germ cell malignancies that occasionally emerge in unexpected extragonadal sites, complicating early recognition and diagnosis. When arising in the vagina, YST may present with misleading symptoms and delayed recognition, given its rarity and concealed anatomical site.
Case Presentation: We present a case of vaginal YST involving a one-year-old girl who presented with prolonged vaginal bleeding and urinary retention.
Cureus
July 2025
Department of Obstetrics and Gynecology, Showa Medical University Fujigaoka Hospital, Yokohama, JPN.
Immature uterine teratoma is an extremely rare extragonadal germ cell tumour with only a small number of reported cases. Given its rarity, standardised treatment guidelines are unavailable, requiring an individualised management approach. Post-treatment assessment remains challenging, particularly in differentiating gliomatosis peritonei, a benign glial implant, from residual malignancy, as this can critically influence subsequent decisions regarding additional surgery or chemotherapy.
View Article and Find Full Text PDFAnn Med Surg (Lond)
August 2025
National Pirigov Memorial Medical University, Vinnytsia, Ukraine.
Introduction: Spinal teratomas are rare tumors of pluripotent germ cells, accounting for <0.5% of all spinal cord tumors and 2% of all teratomas. While they commonly occur in gonads, extragonadal spinal presentation is uncommon.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
July 2025
Department of pediatric surgery, Faculty of Prince of Songkla university, Thailand.
Background: Alpha-fetoprotein (AFP) is commonly used in the management of pediatric extracranial germ cell tumors (eGCT), but its prognostic role remains unclear. We investigated survival outcomes and the impact of serial AFP changes after surgery.
Method: We analyzed data from 129 pediatric eGCT patients (age 0-15) who underwent surgery at our institution.