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Background: Large post-traumatic tibial bone defects combined with soft tissue defects are a common orthopedic clinical problem associated with poor outcomes when treated using traditional surgical methods. The study was designed to investigate the safety and efficacy of trifocal bone transport (TFT) and soft-tissue transport with the Ilizarov technique for large posttraumatic tibial bone and soft tissue defects.
Methods: We retrospectively reviewed 31 patients with massive posttraumatic tibial bone and soft tissue defects from May 2009 to May 2016. All of the eligible patients were managed by TFT and soft-tissue transport. The median age was 33.4 years (range, 2-58 years). The mean defect of bone was 11.87 cm ± 2.78 cm (range, 8.2-18.2 cm) after radical resection performed by TFT. The soft tissue defects ranged from 7 cm × 8 cm to 24 cm × 12 cm. The observed results included bone union time, wound close time and true complications. The Association for the Study and Application of the Method of Ilizarov (ASAMI) scoring system was used to assess bone and functional results and postoperative complications were evaluated by Paley classification.
Results: The mean duration of follow-up after frame removal was 32 months (range, 12-96 months). All cases achieved complete union in both the elongation sites and the docking sites, and eradication of infection. The mean bone transport time was 94.04 ± 23.33 days (range, 63.7-147 days). The mean external fixation time was 22.74 ± 6.82 months (range, 14-37 months), and the mean external fixation index (EFI) was 1.91 ± 0.3 months/cm (range, 1.2-2.5 months/cm). The bone results were excellent in 6 patients, good in 14 patients, fair in 8 patients and poor in 3 patients. The functional results were excellent in 8 patients, good in 15 patients, fair in 5 patients and poor in 3 patients.
Conclusion: TFT, in conjunction with soft tissue transport technique, can give good results in most patients (in this article, good and excellent results were observed in 64% of patients). Soft tissue transport is a feasible method in providing good soft tissue coverage on the bone ends. Although it has no advantages over microvascular techniques, it might be an good alternative in the absence of an experienced flap surgeon. Nonetheless, high-quality controlled studies are needed to assess its long-term safety and efficacy.
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http://dx.doi.org/10.1186/s12891-020-03894-y | DOI Listing |
Ann Surg Oncol
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Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Soft tissue sarcomas (STS) are a heterogeneous group of rare malignant tumors arising from mesenchymal tissues, with extremity and superficial trunk STS (eSTS) comprising the majority of cases. The management of localized eSTS requires a multidisciplinary approach to optimize oncologic and functional outcomes. This review outlines the natural history, diagnostic workup, and treatment principles for localized eSTS, emphasizing the role of histology-specific considerations in guiding management strategies.
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Department of Emergency Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
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Associate Professor, Department of Dental Surgery, Faculty of Dental Surgery, University of Malta, Malta. Electronic address:
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September 2025
Full Professor, School of Mechanical Engineering, Universidad Industrial de Santander, Bucaramanga, Colombia. Electronic address:
Statement Of Problem: Although custom temporomandibular joint (TMJ) prostheses manufactured via computer-aided design and manufacturing (CAD-CAM) and produced through 3-dimensional (3D) printing or computer numerical control (CNC) allow for sagittal curvature adjustments in the glenoid fossa, their design remains unregulated by the Food and Drug Administration. Consequently, the geometry is determined largely by the engineer's discretion, with limited biomechanical evidence to guide these decisions. The lack of validation regarding how sagittal curvature influences joint stress distribution under various anatomical and functional conditions represents a gap in current knowledge that warrants investigation.
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Inserm U955-IMRB, Equipe 03 "Pharmacologie et Technologies pour les Maladies Cardiovasculaires (PROTECT)", Ecole Nationale Vétérinaire d'Alfort (EnVA), Université Paris Est Créteil, F-94700 Maisons-Alfort, France; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France. Electronic address
The aim of this study is to describe a population pharmacokinetic model for intravenous ampicillin-sulbactam in awake and anaesthetized dogs in these two treatment scenarios and to compute PK/PD cut-offs (PK/PD). This was a prospective clinical trial in 20 client-owned dogs, either treated by ampicillin after post-surgical infection, or in the context of surgical antimicrobial prophylaxis. All animals received 20mg/kg of ampicillin by slow iv route.
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