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Objectives: We reviewed hospital records of pediatric cholelithiasis to develop an etiology-based decision-making protocol.
Methods: This retrospective study was conducted on consecutive pediatric cholelithiasis patients from July, 2014 to June, 2019 in a tertiary care center. Pediatric cholelithiasis was classified according to etiology, and the outcome of medical/surgical treatment was noted.
Results: Data of 354 pediatric patients were analyzed. Commonest (56.2%) etiology was idiopathic; followed by ceftriaxone pseudo-lithiasis (26.8%). Pigment stones were associated with the highest rate of complications. Non-hemolytic stones had a lower complication rate and a high rate of resolution with medical therapy.
Conclusions: Hemolytic and symptomatic stones warrant an early cholecystectomy, whereas asymptomatic idiopathic stones, ceftriaxone stones, and TPN-induced stones are candidates for medical therapy under close observation.
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Case Rep Hematol
August 2025
Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
Sickle cell hepatopathy (SCH) is an umbrella term relating to liver disease in sickle cell disease (SCD). This term ranges from common etiologies such as cholelithiasis to disease-specific causes such as sickle cell intrahepatic cholestasis (SCIC), a rare but significant complication of SCD capable of progressing to liver failure and consideration of transplantation. We report the case of a 24-year-old male with SCD who presented with jaundice, encephalopathy, uncontrollable epistaxis, and pseudohematemesis and was found to have hyperbilirubinemia, coagulopathy, portal hypertension, and acute kidney injury (AKI).
View Article and Find Full Text PDFChildren (Basel)
August 2025
Pediatric Surgery Department, "Grigore Alexandrescu" Clinical Emergency Hospital for Children, 011743 Bucharest, Romania.
Background: Pediatric cholelithiasis has become increasingly diagnosed, partly due to enhanced imaging accessibility and rising obesity rates. Despite laparoscopic cholecystectomy being the standard treatment, the optimal timing for surgery remains debated, especially in complicated cases. The aim of our study is to analyze the demographic, clinical, and surgical characteristics of pediatric patients undergoing cholecystectomy and to identify the most favorable timing for surgery in terms of outcomes and complications.
View Article and Find Full Text PDFBMJ Case Rep
August 2025
Pediatrics, Hospital Tuanku Ja'afar Seremban, Seremban, Malaysia
J Pediatr Surg
August 2025
Division of Pediatric Surgery, Rady Children's Hospital San Diego, La Jolla, CA; Division of Pediatric Surgery, Dept of General Surgery, UCSD School of Medicine, La Jolla, CA. Electronic address:
Background: Guidelines for adult gallstone pancreatitis (GP) in adults recommend endoscopic retrograde cholangiopancreatography (ERCP) for ongoing biliary obstruction. Studies in children are limited by small sample sizes. We sought to explore whether factors predictive of choledocholithiasis (CDL) are correlated with ERCP findings of stones in pediatric GP.
View Article and Find Full Text PDFObesity (Silver Spring)
September 2025
Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Objective: Although associations of adiposity with metabolic, cardiovascular, and liver diseases are known, the genetic links, causal effects, and polygenic risk score (PRS) predictions for these health conditions in East Asian individuals remain unclear.
Methods: We conducted genome-wide association studies of BMI (n = 95,488) and body fat percentage (BFP; n = 83,448) in Taiwanese individuals from Taiwan Biobank data, followed by cross-trait genetic correlation and bidirectional Mendelian randomization in four East Asian biobanks. BMI and BFP PRS were constructed and validated in the China Medical University Hospital and Biobank Japan databases.