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Background/aim: In this study, a new method to create a customized three-dimensional (3D) bolus by accurately considering the anatomy of an individual patient is demonstrated.
Patients And Methods: A 3D bolus structure was created from an extended planning target volume (PTV) to reduce an inevitable skin reaction. In addition, during computed tomography simulation in patients with oral cavity cancers, a balloon was inserted into the mouth of a patient to secure space, and then the area surrounding the balloon was designed into a 3D bolus structure.
Results: For patients with head and neck cancers, a customized 3D bolus can reduce the unnecessary skin dose by 14.4% compared to a commercial bolus. For patients with oral cavity cancer, the PTV and tongue doses were 93.8% and 8% of the prescribed dose, respectively.
Conclusion: The customized 3D bolus enables effective skin sparing and full coverage of the target area.
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http://dx.doi.org/10.21873/invivo.12294 | DOI Listing |
Int J Surg
September 2025
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Aim: This study investigates the application of three-dimensional (3D) printing in cancer research and treatment, highlighting the current advancements, key areas of interest, and emerging trends in the field.
Methods: Literature records and cited references were retrieved from the Web of Science Core Collection (WOSCC) database and analyzed using Excel 2019, Bibliometrix, VOSviewer, and CiteSpace. Based on the scientometric results, a stratified and focused thematic analysis was performed by cancer type to enhance clinical relevance and investigate tumor-specific applications.
Med Phys
September 2025
Department of Radiation Oncology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting over 32 million Americans. Low dose radiation therapy (LDRT) is being used to treat OA, including small joints. Treatment energies recommended include both orthovoltage and 6 MV photons.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Department of Biological SciencesNorthern Arizona University, Flagstaff, Arizona, United States.
Safe and effective infant feeding requires precise coordination of sucking, swallowing, and breathing, yet disruptions in this coordination affect a significant number of infants. Altering sensory input, such as bottle nipple flow rate, is used to address poor coordination in infants. However, prior studies often compare different nipples used across different feeds, which introduces confounding variables and limits insight into neuromotor responses.
View Article and Find Full Text PDFTech Innov Patient Support Radiat Oncol
September 2025
Faculty of Physics, Babeș-Bolyai University, Cluj-Napoca, Romania.
Treating multiple scalp metastasis in patients is challenging due to the large area that needs to be treated and the complex structure of the scalp. Dose coverage with coplanar fields is hard to optimize with the Halcyon machine's three degrees of freedom (3DoF) couch movement. A potential solution is to use a 3D-printed bolus, which can be designed to fit the scalp contour.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University Research Headquarters, University of Antioquia, Calle 70#52-21 and Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.
In familial Alzheimer's disease (FAD), presenilin 1 (PSEN1) E280A cholinergic-like neurons (ChLNs) induce aberrant secretion of extracellular amyloid beta (eAβ). How PSEN1 E280A ChLNs-eAβ affects microglial activity is still unknown. We obtained induced microglia-like cells (iMG) from human peripheral blood cells (hPBCs) in a 15-day differentiation process to investigate the effect of bolus addition of Aβ42, PSEN1 E280A cholinergic-like neuron (ChLN)-derived culture supernatants, and PSEN1 E280A ChLNs on wild type (WT) iMG, PSEN1 E280A iMG, and sporadic Alzheimer's disease (SAD) iMG.
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