Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Antibodies specific to phage virions have been observed many times, both in animals and in humans. Phages induce the T-dependent type of immune response, which is fundamental for immunological memory and long retention of abilities to recognize and respond to foreign epitopes. Experimental models have shown that phage-specific antibodies can be devastating for a phage in vivo. Observations from phage treatment in humans demonstrate however that antibodies do not necessarily hinder phage therapy. Controlling effective doses may help in controlling the immune response to phage and to create 'therapeutic windows' for the phage. Phage therapy design may also benefit from understanding phage antigenicity and predicting possible cross-reactions between antibodies specific to different phages.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.copbio.2020.11.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative analysis of immune responses to intraperitoneal administration of lytic E. coli bacteriophages in mice.
Virus Res
September 2025
Research and Production Center for Microbiology and Virology, Almaty, Kazakhstan. Electronic address:
With the global spread of bacterial resistance and the decreasing effectiveness of antibiotics, the relevance of phage therapy is constantly growing. However, for systemic use of bacteriophages in medical practice, a complete understanding of their interaction not only with bacterial cells but also with human and animal organisms in the context of co-administered therapy is required. This article presents the studies into the effects of lytic Escherichia coli bacteriophages on various immune response factors after their intraperitoneal administration in mice.
View Article and Find Full Text PDFPre-exposure to phage particles reduces their antibacterial therapeutic efficacy both in vitro and in vivo.
Int J Med Microbiol
March 2025
Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Objectives: phage therapy is a promising approach for infections caused by drug-resistant bacteria; this study evaluated the impact of pre-exposure to phage particles on subsequent therapy. Mice were exposed intradermally (i.d.
View Article and Find Full Text PDFPhage-specific antibodies: are they a hurdle for the success of phage therapy?
Essays Biochem
December 2024
Laboratory of Phage Biologics, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan.
Phage therapy has attracted attention again owing to the increasing number of drug-resistant bacteria. Although the efficacy of phage therapy has been reported, numerous studies have indicated that the generation of phage-specific antibodies resulting from phage administration might have an impact on clinical outcomes. Phage-specific antibodies promote phage uptake by macrophages and contribute to their rapid clearance from the body.
View Article and Find Full Text PDFPhage-specific immunity impairs efficacy of bacteriophage targeting Vancomycin Resistant Enterococcus in a murine model.
Nat Commun
April 2024
Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccines Research and Review, Division of Bacterial Parasitic and Allergenic Products, Laboratory of Mucosal Pathogens and Cellular Immunology, 10903 New Hampshire Ave, Silver Spring, MD, 20832, USA. paul.carlson@f
Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of the immune response on clinical effectiveness. Here, we develop a mouse model to assess phage treatment using a cocktail of five phages from the Myoviridae and Siphoviridae families that target Vancomycin-Resistant Enterococcus gut colonization. Phage treatment significantly reduces fecal bacterial loads of Vancomycin-Resistant Enterococcus.
View Article and Find Full Text PDFArbitrium communication controls phage lysogeny through non-lethal modulation of a host toxin-antitoxin defence system.
Nat Microbiol
January 2024
Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv, Israel.
Temperate Bacillus phages often utilize arbitrium communication to control lysis/lysogeny decisions, but the mechanisms by which this control is exerted remains largely unknown. Here we find that the arbitrium system of Bacillus subtilis phage ϕ3T modulates the host-encoded MazEF toxin-antitoxin system to this aim. Upon infection, the MazF ribonuclease is activated by three phage genes.
View Article and Find Full Text PDF