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Objective: Alcohol remains the most commonly substance used by adolescents.The aim of the study was to draw a comprehensive picture of the behavioural patterns that characterize alcohol use and abuse among 15-year-olds.
Materials And Methods: The study sample included 18,918 15-year-olds participating in the 2018 Italian Health Behaviour in School-aged Children (HBSC) survey. A Bayesian approach was adopted for selecting the manifest variables associated with alcohol consumption; a latent class regression model was employed to identify health-related risk patterns associated with alcohol use.
Results: 21% of our sample represented the cluster of heavy drinkers who shared other risk behaviours: heavy smoking habits (29%), cannabis (68%), gambling (52%) and drunkenness (76%) experience, binge drinking (96%) and sexual intercourse (51%).
Conclusions: Our results confirm multiple risk-taking behaviours among adolescents tending to cluster in behavioural patterns. This has implications for public health policies and must be considered when planning interventions and prevention strategies.
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http://dx.doi.org/10.4415/ANN_20_04_18 | DOI Listing |
J Neurol
September 2025
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Background: The "Systematic Screening of Handwriting Difficulties in Parkinson's Disease" (SOS) test is the only tool specifically designed to evaluate handwriting in people with Parkinson's Disease (pwPD). It is language specific.
Objective: To assess the construct validity, intrarater and interrater reliability of the Italian version of the SOS test.
J Affect Disord
September 2025
King's College London, Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, London, SE5 9RT, UK; National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College Lond
Although inflammation has been suggested as a promising therapeutic target for major depressive disorder (MDD), uncertainty remains about how to recognise individuals who may benefit from anti-inflammatory treatments. Transcriptomic profiles provide an important tool to identify relevant biological mechanisms associated with response. In this study, we investigate: i) the ability of transcriptomic profiles to predict antidepressant response to anti-inflammatory treatment with minocycline, and ii) the effect of minocycline on transcriptomic profiles based on the antidepressant response.
View Article and Find Full Text PDFTumori
September 2025
National Center for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy.
Introduction: An indirect approach was applied to the case-study of thyroid cancer (TC) and melanoma of the skin (MS) in Italy to identify health services (HS) for cancer patients and to enable cost estimation.
Materials And Methods: Within the Epicost-2 project, a self-controlled crossover design analysed TC and MS 2018 prevalent cases from Italian cancer registries. Controls (1:1) were matched to cases 18-6 months prior to diagnosis; increases between cases and controls in potentially cancer-related HS claims (P⩽5%) were identified.
Eur J Med Chem
August 2025
Department of Life Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, 41125, Modena, Italy. Electronic address:
The transcriptional activity of TEAD4 (transcriptional enhancer associated domain proteins), one of the final effectors of the Hippo pathway, can be dysregulated or mutated in cancer. Consequently, targeting the interaction between TEAD and its co-activator YAP (Yes Associated Protein) to disrupt the YAP:TEAD (Y:T) heterodimer has emerged as a promising anti-cancer strategy. Therefore, in this study, we aimed to identify novel scaffolds targeting the TEAD Interface 3 surface as effective anticancer agents against colorectal and ovarian cancer.
View Article and Find Full Text PDFNeurology
September 2025
Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom.
Background And Objectives: Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular health, and its signature in familial frontotemporal dementia (FTD) remains unknown. The primary aim was to investigate CVR in genetic FTD using an fMRI index of vascular contractility termed resting-state fluctuation amplitudes (RSFAs) and to assess whether RSFA differences are moderated by age. A secondary aim was to study the relationship between RSFA and cognition.
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