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Intracoronary wave intensity analysis in hypertrophic cardiomyopathy has shown a large backward compression wave due to compressive deformation of the intramyocardial coronary arteries in systole. The authors describe the angiographic evidence of this backward compression wave, which has not been described in this physiological context and can be a marker of poor prognosis.
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http://dx.doi.org/10.1017/S104795112000428X | DOI Listing |
Background: Pulmonary wave intensity analysis uses pressure and velocity data to assess the intensity, direction, type, and timing of waves. Its application in early and undifferentiated pulmonary hypertension (PH) to characterize right ventricular (RV)-pulmonary arterial (PA) interactions has not been previously reported.
Methods: We hypothesized that wave intensity and speed would increase with mean PA pressure, while reflected wave timing would remain unchanged.
Lab Chip
August 2025
Department of Bioengineering, Santa Clara University, CA 95053, USA.
The volume of natural materials increases under tension, thus conventionally biomechanical actuation of fluidic pumps relies on compression for pressure generation. Here, we report on out-of-surface microchannels (OSMiCs) that exhibit negative volumetric strain (, pressure generation) under skin-induced tensile strain. Monolithic polydimethylsiloxane (PDMS) patches were fabricated and characterized.
View Article and Find Full Text PDFAlgorithms Mol Biol
August 2025
Ghent University-imec, Technologiepark 126, 9052, Ghent, Belgium.
Background: Due to the increasing availability of high-quality genome sequences, pan-genomes are gradually replacing single consensus reference genomes in many bioinformatics pipelines to better capture genetic diversity. Traditional bioinformatics tools using the FM-index face memory limitations with such large genome collections. Recent advancements in run-length compressed indices like Gagie et al.
View Article and Find Full Text PDFPhys Rev Lett
June 2025
Shanghai Jiao Tong University, National Key Laboratory of Dark Matter Physics, School of Physics and Astronomy, Shanghai 200240, China.
Light amplification toward extremely high power in the infrared regime remains a significant challenge due to the lack of suitable gain media. Here we propose a new scheme to amplify a laser pulse with tunable wavelengths toward extremely high power via forward Raman amplification in plasma. Different from previously proposed schemes based upon backward Raman or Brillouin amplification, our scheme involves a pump pulse and a seed pulse copropagating in moderate density plasma, with the phase matching conditions for forward Raman scattering fulfilled.
View Article and Find Full Text PDFEur Biophys J
July 2025
Institute of Biophysics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
A foundational understanding of biophysics and fluid dynamics is critical for comprehending cardiovascular physiological phenomena, yet medical students often struggle with the mathematical complexity. Traditional teaching methods, including in vivo and in vitro experiments, are increasingly being replaced due to ethical concerns, leading to the adoption of in silico models. This study developed a biophysical model simulating the vascular tree using pumps and silicone vessels.
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