Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.23736/S0026-4806.20.07103-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Objective: Methylphenidate is effective in reducing ADHD symptoms in the short term, but long-term benefits are inconsistent, possibly due to the development of tolerance. Moreover, little is known about its sustained effects on brain functional connectivity. We examined whether a 4-month methylphenidate treatment leads to sustained alterations in resting-state functional connectivity, and whether acute brain responses to methylphenidate decrease after treatment, as a potential marker of neurobiological tolerance.
View Article and Find Full Text PDFSystemic physiological "noise" in fMRI has clinical relevance.
medRxiv
August 2025
Neuroimaging Research Branch, National Institute on Drug Abuse (NIDA), Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a component of the fMRI signal-the systemic low-frequency oscillation (sLFO), linked to blood flow and physiological measures of arousal-indexes trait- and state-level drug use phenotypes. In individuals who chronically use nicotine, sLFO amplitude increased during abstinence and correlated with heightened dependence severity and cue-induced craving.
View Article and Find Full Text PDFThe impact of methylphenidate on oral health parameters, salivary flow rate, and quality of life in children with attention-deficit/hyperactivity disorder: a cross-sectional study.
Clin Oral Investig
September 2025
Department of Pediatric Dentistry, School of Dentistry, Marmara University, Istanbul, Türkiye.
Objectives: This study aimed to evaluate and compare the effects of methylphenidate on oral health, salivary flow rate, and quality of life in children with Attention-Deficit/Hyperactivity Disorder (ADHD), focusing on differences between short-release methylphenidate (SRM) and long-release methylphenidate (LRM) formulations.
Materials And Methods: A total of 99 children participated in this cross-sectional study (ADHD: n = 49; divided into SRM (n = 27) and LRM (n = 22) subgroups based on medication type; control: n = 50). Dental caries was assessed using the DMFT/dft indices and the International Caries Detection and Assessment System (ICDAS), while oral hygiene was evaluated using the Plaque Index (PI), Gingival Index (GI), and Bleeding on Probing (BOP).
Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia.
Neurobiol Dis
September 2025
Inserm UMR-S 1270, Paris 75005, France; Sorbonne Université, Faculty of Sciences and Engineering, Paris 75005, France; Institut du Fer à Moulin, 17 rue du Fer à Moulin, Paris 75005, France; Sorbonne Université, Institut du Cerveau, Inserm, CNRS, AP-HP, Institut de Neurologie, Hôpital de la Salp
Isolated dystonia can be caused by loss-of-function mutations in the GNAL gene (DYT-GNAL/DYT25). This gene encodes the α subunit of the heterotrimeric G protein, which, with βγ subunits, mediates the stimulatory coupling of dopamine D1 and adenosine A2A receptors to adenylyl-cyclase. These receptors are expressed in distinct striatal projection neurons (SPNs) with complementary functions in motor behavior.
View Article and Find Full Text PDFOccurrence of Psychosis and Bipolar Disorder in Individuals With Attention-Deficit/Hyperactivity Disorder Treated With Stimulants: A Systematic Review and Meta-Analysis.
JAMA Psychiatry
September 2025
Developmental Evidence Synthesis, Prediction, Implementation Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom.
Importance: Individuals with attention-deficit/hyperactivity disorder (ADHD) may present with psychosis or bipolar disorder (BD) following treatment with stimulants. The extent to which this occurs is currently unclear.
Objective: To meta-analytically quantify the occurrence of psychosis or BD after exposure to stimulants in individuals with ADHD and assess possible moderating factors.