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An approach is proposed and illustrated for the joint selection of essential samples and essential variables of a data matrix in the frame of spectral unmixing. These essential features carry the signals required to linearly recover all the information available in the rows and columns of a data set. Working with hyperspectral images, this approach translates into the selection of essential spectral pixels (ESPs) and essential spatial variables (ESVs). This results in a highly-reduced data set, the benefits of which can be minimized computational effort, meticulous data mining, easier model building as well as better problem understanding or interpretation. Working with both simulated and real data, we show that (i) reduction rates of over 99% can be typically obtained, (ii) multivariate curve resolution - alternating least squares (MCR-ALS) can be easily applied on the reduced data sets and (iii) the full distribution maps and spectral profiles can be readily obtained from the reduced profiles and the reduced data sets (without using the full data matrix).
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http://dx.doi.org/10.1016/j.aca.2020.10.040 | DOI Listing |
J Appl Clin Med Phys
September 2025
Icon Cancer Centre Toowoomba, Toowoomba, Queensland, Australia.
Introduction: The role of imaging in radiotherapy is becoming increasingly important. Verification of imaging parameters prior to treatment planning is essential for safe and effective clinical practice.
Methods: This study described the development and clinical implementation of ImageCompliance, an automated, GUI-based script designed to verify and enforce correct CT and MRI parameters during radiotherapy planning.
EMBO J
September 2025
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
During a critical period of postnatal brain development, neural circuits undergo significant refinement coincident with widespread alternative splicing of hundreds of genes, which undergo altered splice site selection for the generation of isoforms essential for synaptic plasticity. Here, we reveal that neuronal activity-dependent phosphorylation of paxillin at its serine 119 (p-paxillin) acts as a molecular switch in the nucleus for the control of alternative splicing during this period. We show that following NMDA receptor activation, nuclear p-paxillin is recruited to nuclear speckles, where it interacts with splicing factors, such as U2AFs.
View Article and Find Full Text PDFEMBO J
September 2025
New York University Grossman School of Medicine, Microbiology Department, New York, NY, USA.
Serine protease inhibitors (SERPINs) are involved in various physiological processes and diseases, such as inflammation, cancer metastasis, and neurodegeneration. Their role in viral infections is poorly understood, as their expression patterns during infection and the range of proteases they target have yet to be fully characterized. Here, we show widespread expression of human SERPINs in response to respiratory virus infections, both in bronchioalveolar lavages from COVID-19 patients and in polarized human airway epithelial cultures.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2025
Hospital Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Introduction: Metastatic breast cancer (mBC) is a major global health challenge. Antibody-drug conjugates (ADCs), including trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and sacituzumab govitecan (SG), offer clinical benefits but are associated with high costs, making cost-effectiveness assessments essential for policy decisions.
Methods: This systematic review analyzed economic evaluations comparing T-DM1, T-DXd, and SG with conventional treatments in breast cancer.
J Chem Inf Model
September 2025
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, United States.
The development of low-cost, high-performance materials with enhanced transparency in the long-wavelength infrared (LWIR) region (800-1250 cm/8-12.5 μm) is essential for advancing thermal imaging and sensing technologies. Traditional LWIR optics rely on costly inorganic materials, limiting their broader deployment.
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