Is There a Role for Locoregional Therapies for Non-colorectal Gastrointestinal Malignancies?

Surg Oncol Clin N Am

Digestive Surgery Division, Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo Medical School, Avenida Doutor Enéas de Carvalho Aguiar, 255, Instituto Central, 9° andar, Sala 9074, Cerqueira Cesar, São Paulo, São Paulo CEP: 05403-900, Brazil. Electronic address: pherman@

Published: January 2021


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

The liver is the most common site of metastases from solid gastrointestinal tract tumors. Over the past few decades, the role of locoregional therapies, resection and thermal ablation, for neuroendocrine and colorectal liver metastases has been widely studied. However, for liver metastases originating from other gastrointestinal organs, the role of locoregional treatment remains unclear. This review summarizes and discusses the available evidence regarding benefits, risks, and indications for locoregional therapies for non-colorectal and non-neuroendocrine gastrointestinal liver metastases, highlighting the importance of multidisciplinary approach and patient selection.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.soc.2020.08.004DOI Listing

Publication Analysis

Top Keywords

role locoregional
12
locoregional therapies
12
liver metastases
12
therapies non-colorectal
8
gastrointestinal
4
non-colorectal gastrointestinal
4
gastrointestinal malignancies?
4
liver
4
malignancies? liver
4
liver common
4

Similar Publications

Background: Local control strategies in pediatric oncology are guided by disease-specific considerations. Effective communication of the goals of surgical procedure and associated intraoperative events plays a crucial role in shaping subsequent treatment decisions. However, accurately and comprehensively documenting these findings remains challenging, with considerable variability across different tumor types.

View Article and Find Full Text PDF

The role of brain MR and FDG-PET in the diagnosis of neurodegenerative disease.

Eur Radiol

September 2025

Department of Radiology and Imaging Sciences, University of Utah, 30N Mario Capecchi Drive, 2 South, Salt Lake City, UT, USA.

Alzheimer disease (AD) is the most common dementing disorder, affecting 55 million people worldwide. Brain MRI plays an integral role in the diagnostic evaluation of patients with cognitive symptoms. When interpreting brain MRI for cognitive impairment, radiologists should assess the following four key features: (1) white matter ischemic burden, (2) structural changes to suggest normal pressure hydrocephalus, (3) locoregional pattern of brain atrophy, and (4) presence of microhemorrhage or superficial siderosis, particularly for determining eligibility for anti-amyloid monoclonal antibody (MAB) treatment when appropriate.

View Article and Find Full Text PDF

Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, necessitating innovative treatment strategies. Surgical resection and liver transplantation continue to be the gold standards for early-stage HCC; however, advances in imaging and minimally invasive techniques have improved patient selection and outcomes. Additionally, the emergence of targeted therapies and immunotherapy has transformed the treatment landscape for advanced HCC.

View Article and Find Full Text PDF

Hot spots and trends related to chemotherapy in nasopharyngeal carcinoma [2014-2024]: a bibliometric study.

Chin Clin Oncol

August 2025

Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China; Institute of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Background: Chemotherapy has played an essential role in nasopharyngeal carcinoma (NPC) management since the 1980s, when its radiosensitizing effects were first recognized. The landmark Intergroup 0099 trial established concurrent cisplatin-based chemoradiotherapy as the standard for locoregionally advanced NPC, demonstrating significant survival benefits over radiotherapy alone. As an Epstein-Barr virus (EBV)-associated malignancy with distinct geographical distribution (endemic in southern China and Southeast Asia), NPC presents unique therapeutic challenges.

View Article and Find Full Text PDF

Background And Objective: Transarterial chemoembolization (TACE) is a locoregional therapy used in patients with unresectable intermediate-stage hepatocellular carcinoma (HCC). It has proven benefit on overall survival, but considerable side effects and potential complications may occur. Preservation of quality of life is a concern in many cancer-related therapies, and the same goal should apply in TACE.

View Article and Find Full Text PDF