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Directional locking occurs when a particle moving over a periodic substrate becomes constrained to travel along certain substrate symmetry directions. Such locking effects arise for colloids and superconducting vortices moving over ordered substrates when the direction of the external drive is varied. Here we study the directional locking of run-and-tumble active matter particles interacting with a periodic array of obstacles. In the absence of an external biasing force, we find that the active particle motion locks to various symmetry directions of the substrate when the run time between tumbles is large. The number of possible locking directions depends on the array density and on the relative sizes of the particles and the obstacles. For a square array of large obstacles, the active particle only locks to the x, y, and 45^{∘} directions, while for smaller obstacles, the number of locking angles increases. Each locking angle satisfies θ=arctan(p/q), where p and q are integers, and the angle of motion can be measured using the ratio of the velocities or the velocity distributions in the x and y directions. When a biasing driving force is applied, the directional locking behavior is affected by the ratio of the self-propulsion force to the biasing force. For large biasing, the behavior resembles that found for directional locking in passive systems. For large obstacles under biased driving, a trapping behavior occurs that is nonmonotonic as a function of increasing run length or increasing self-propulsion force, and the trapping diminishes when the run length is sufficiently large.
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http://dx.doi.org/10.1103/PhysRevE.102.042616 | DOI Listing |
Eur J Orthop Surg Traumatol
September 2025
Department of Orthopaedics, Jupiter Hospital, Thāne, India.
We aim to describe an approach for reducing the posteriorly dislocated humeral head through the rotator interval via a deltopectoral approach that is frequently utilized for internal fixation of proximal humerus fractures and fracture dislocations. The sheath of the long head of biceps (LHB) and the rotator interval capsule are opened till the glenoid; this enables access to the glenohumeral joint via the rotator interval. A long-handle Cobb elevator is introduced through the rotator interval and, under intraoperative imaging, advanced posteromedially to the dislocated humeral head.
View Article and Find Full Text PDFJ Comput Neurosci
September 2025
School of Electrical and Information Engineering, Tianjin University, Tianjin, 300072, China.
Transcranial alternating current stimulation (tACS) enables non-invasive modulation of brain activity, holding promise for cognitive research and clinical applications. However, it remains unclear how the spiking activity of cortical neurons is modulated by specific electric field (E-field) distributions. Here, we use a multi-scale computational framework that integrates an anatomically accurate head model with morphologically realistic neuron models to simulate the responses of layer 5 pyramidal cells (L5 PCs) to the E-fields generated by conventional M1-SO tACS.
View Article and Find Full Text PDFUnfallchirurgie (Heidelb)
September 2025
Klinik für Unfall‑, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude W1, 48149, Münster, Deutschland.
The bony consolidation of fractures depends on various factors. Under optimal conditions fracture healing takes place within a few weeks. An essential requirement for fracture healing is the restoration of adequate biomechanical stability with an interfragmentary movement which is as ideal as possible.
View Article and Find Full Text PDFmBio
September 2025
School of Life Sciences, University of Warwick, Coventry, United Kingdom.
The FtsEX-EnvC-AmiA/B system is a key component of the cell division machinery that directs breakage of the peptidoglycan layer during separation of daughter cells. Structural and mechanistic studies have shown that ATP binding by FtsEX in the cytoplasm drives periplasmic conformational changes in EnvC, which lead to the binding and activation of peptidoglycan amidases such as AmiA and AmiB. The FtsEX-EnvC amidase system is highly regulated to prevent cell lysis with at least two separate layers of autoinhibition that must be relieved to initiate peptidoglycan hydrolysis during division.
View Article and Find Full Text PDFActa Crystallogr E Crystallogr Commun
September 2025
Department of Chemistry Faculty of Science University of Lucknow,Lucknow 226007 Uttar Pradesh India.
The crystal structure of entinostat Form B, CHNO, has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques. Entinostat crystallizes in space group 2 and the crystal structure consists of inter-locking layers of entinostat mol-ecules parallel to the plane. A strong N-H⋯N hydrogen bond links the mol-ecules into zigzag chains propagating along the -axis direction.
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