The Dueling Duo: IL10 and TNF Face Off in Microglial Recovery from Endotoxin Challenge.

Immunity

Department of Neurology, Stanford University, Stanford, CA, USA; Wu-Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA; Program in Immunology, Stanford University, Stanford, CA, USA. Electronic address:

Published: November 2020


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Article Abstract

The molecular mechanisms that restore microglial quiescence after acute stimulation remain largely unexplored, unlike those that drive microglial activation. In this issue of Immunity, Shemer et al. discover that the microglial IL-10 receptor counteracts the pro-inflammatory effects of TNF to allow restoration of microglial quiescence after peripheral endotoxin challenge.

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http://dx.doi.org/10.1016/j.immuni.2020.10.016DOI Listing

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