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Low back pain (LBP) is the leading cause of disability and one of the most common reasons for physician visits in primary care, with a 33% rate of recurrence during the first year. However, the most optimal exercise program in this context remains unknown. The objective was to evaluate the effectiveness of a group-based progressive strength training program in non-specific chronic LBP (CLBP) patients in primary care on pain recurrence and physical function. Eighty-five patients with non-specific CLBP were separated into two groups (Intervention group: completed a progressive strength training program 3 days per week for 8 weeks; Control group: received the usual care). The intervention group showed a recurrence rate of 8.3%, while the control group had a recurrence rate of 33.3% and a shorter time until the first recurrent episode. The intervention group showed increased lumbar extensor strength, left-hand handgrip strength, and reduced the number of pain sites compared with the control group. Results also showed greater odds for reducing LBP intensity and disability in the intervention group. In conclusion, a group-based progressive strength training program is a more effective and efficient alternative than Back-School programs and can easily be carried out in the primary health care context.
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http://dx.doi.org/10.3390/ijerph17228326 | DOI Listing |
Front Mol Biosci
August 2025
Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Recent advances in artificial intelligence (AI) are reshaping the diagnostic and therapeutic of primary aldosteronism (PA). For screening, machine learning models integrate multidimensional data to improve the efficiency of PA detection, facilitating large-scale population screening. For diagnosis, AI-driven algorithms have further enhanced the specificity of PA identification.
View Article and Find Full Text PDFA 52-year-old Myanmar man presented with bilateral progressive painless asymmetrical wrist and finger drop in 1 year without any sensory and sphincter problems. He has hypochromic microcytic anemia diagnosed as Hemoglobin E disease before. However, a serial full blood count revealed thrombocytopenia and a drop in hemoglobin disproportionate to HbE disease.
View Article and Find Full Text PDFOpen Access J Sports Med
August 2025
Division of Occupational Therapy and Physical Therapy; Division of Sports Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Background: Although exercises and physical activities are beneficial for overall health, it can unfortunately result in a musculoskeletal injury that requires a surgical intervention in physically active youth. One of the major injures young athletes sustain is anterior cruciate ligament (ACL) tear, which often requires a surgical intervention. Following the ACL reconstruction (ACLR) surgery, athletes need to participate in rehabilitation and often perform return-to-sport (RTS) testing.
View Article and Find Full Text PDFFront Pharmacol
August 2025
The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
Hyperuricemia (HUA) is a prevalent metabolic disorder driven by dysregulated purine metabolism and impaired urate excretion, and robust animal models are critical for elucidating its pathophysiology and guiding therapy development. This review systematically examines chemically induced, gene-edited, environmental, exercise and microbiota-based HUA models across rodents, poultry, primates, zebrafish and silkworms, highlighting each model's strengths and limitations in mimicking human uric acid handling. We discuss how these models have validated standard urate-lowering treatments-such as xanthine oxidase inhibitors and uricosurics-and uncovered emerging therapeutic targets, including the gut-NLRP3 inflammasome axis and SIRT1-mediated ABCG2 regulation.
View Article and Find Full Text PDFMater Today Bio
October 2025
Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.
Unlabelled: Disuse muscle atrophy (DMA) is characterized by progressive loss of muscle mass and strength, often accompanied by inflammation and macrophage imbalance. Here, we introduce hydrogenated silicene nanosheets (H-silicene) as a novel nanotherapeutic strategy to mitigate DMA through modulating macrophage polarization. H-silicene exhibited good biocompatibility and sustained hydrogen release.
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