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Although light emitting diodes (LEDs) are widely used in our daily lives, there is little research regarding LED light's possible effects on biological functions. We used a zebrafish animal model to investigate the long-term effects of white, blue and red LED lights on cognitive learning and memory recall. Our data suggest that these treatments had not only an impact on learning but also surprisingly long-lasting effects, particularly with regard to individuals treated with red light. The qPCR results revealed that the expression levels of trpm4, trpa1b, grin2aa and dlg4 in the skin were increased after monochromatic light treatment. Furthermore, the up-regulation of trpm4 in the brain may correlate to enhanced learning and memory following red-light treatment. Our results identify a light-based stimulation system for enhancing zebrafish learning, which has the potential to provide important insights into the relationship between LED lighting and animal behaviour.
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http://dx.doi.org/10.1016/j.jphotobiol.2020.112073 | DOI Listing |
Int J Dermatol
July 2025
Brigham and Women's Hospital, Boston, Massachusetts, USA.
Mol Ther Methods Clin Dev
June 2025
Université Paris-Saclay, University Evry, Inserm, Genethon, Integrare Research Unit UMR_S951, 91000 Evry, France.
Pompe disease is a glycogen storage disorder caused by mutations in the acid α-glucosidase (GAA) gene, leading to reduced GAA activity and glycogen accumulation in heart and skeletal muscles. Enzyme replacement therapy with recombinant GAA, the standard of care for Pompe disease, is limited by poor skeletal muscle distribution and immune responses after repeated administrations. The expression of GAA in muscle with adeno-associated virus (AAV) vectors has shown limitations, mainly the low targeting efficiency and immune responses to the transgene.
View Article and Find Full Text PDFPLoS One
September 2025
Satellite Collections North, Genebank Department, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Malchow/Poel, Germany.
Treatment of seeds with cold atmospheric pressure plasma (CAPP) is in its proof-of-concept phase with regard to its effect on germination and plant growth. To increase the germination of hardseeded red clover (Trifolium pratense L.), seeds are usually scarified, which is time-consuming and labour-intensive.
View Article and Find Full Text PDFPest Manag Sci
September 2025
IRTA, Fruit Production Program, Fruitcentre, Lleida, Catalonia, Spain.
Background: Red leaf blotch (RLB), caused by Polystigma amygdalinum, is a major foliar disease of almond trees in Mediterranean and Middle Eastern regions. While preventive fungicide applications are the main control strategy, cultural practices aimed at reducing pathogen inoculum in leaf litter are gaining relevance. This study evaluated the efficacy of four chemical treatments on fungal biomass and ascospore production in leaf litter and assessed the impact of two cultural practices-urea application and leaf litter removal-on airborne inoculum levels and disease incidence under field conditions.
View Article and Find Full Text PDFComp Biochem Physiol C Toxicol Pharmacol
September 2025
Occupational Health, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 60126, Ancona, Italy. Electronic address:
Artificial light at night (ALAN) can disrupt numerous biological processes, and is increasingly studied in animal models. Here, we evaluated the impact of red and blue ALAN on Drosophila melanogaster, focusing on fertility, development, circadian rhythms, and gene expression. All results were compared to those of a control group maintained under a 12 h white light/12 h dark cycle.
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