98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647442 | PMC |
http://dx.doi.org/10.1016/j.cmi.2020.10.031 | DOI Listing |
Ital J Pediatr
September 2025
Department of Pulmonology, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Background: In pulmonary surfactants, surfactant protein C (SP-C) plays a critical role in regulating surface tension at the air-liquid interface of alveoli, primarily due to its robust hydrophobic property. Genetic mutations in the SP-C gene can compromise its structural integrity, thereby impairing its functional efficiency in surface tension modulation.
Method: A retrospective analysis was performed on 11 pediatric patients harboring SP-C gene mutations who were admitted to our medical center between June 2014 and June 2024.
Objectives: To assess treatment and identify predictive factors of worsening in COVID-19 patients.
Methods: This study was ambispective (both prospective and retrospective) and part of a multidisciplinary, multicenter project designed to generate epidemiological, sociological and anthropological data about the COVID-19 epidemic in Burkina Faso. Medical records of patients admitted for COVID-19 at the hospitals of Ouagadougou and Bobo-Dioulasso from March 2020 to April 2021 were reviewed.
Pak J Pharm Sci
July 2025
Department of Pharmacy Practice, Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan.
The study was conducted to evaluate the prevalence of Drug-Drug Interactions (DDIs) of Azithromycin and its impact on patient mortality and microbial resistance during the first wave of COVID-19. The study was performed in tertiary care hospitals located in various areas of Karachi, Pakistan. A cross sectional retrospective study on a sample size of 300 patients was conducted (Jan - Dec 2020) on in-patients receiving Azithromycin as part of their therapeutic regimen.
View Article and Find Full Text PDFItal J Pediatr
July 2025
Department of Pediatrics, Cystic Fibrosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Background: Childhood interstitial lung disease (chILD) encompasses a heterogeneous group of rare disorders characterized by respiratory distress, hypoxemia, exercise intolerance, and distinctive radiological findings. Despite the variable age of onset, these conditions often present with overlapping symptoms and variable progression, even with identical genetic mutations. Surfactant protein deficiencies fall under the category of chILD, with Surfactant Protein-C (SP-C) deficiency posing significant diagnostic challenges due to its rarity and the variable severity of clinical presentation.
View Article and Find Full Text PDFWorld J Virol
June 2025
School of Public Health and Health Sciences, California State University, Los Angeles, CA 90747, United States.
The novel coronavirus disease 2019 (COVID-19) causes serious respiratory illness and related disorders. Vulnerable populations, including those with chronic obstructive pulmonary disease, heart disease, diabetes, chronic kidney disease, obesity, and the elderly, face an increased risk of severe complications. As the pandemic evolves, various diagnostic techniques are available to detect severe acute respiratory distress syndrome (SARS-CoV-2), including clinical presentation, rapid antigen/antibody testing, molecular testing, supplemental laboratory analysis, and imaging.
View Article and Find Full Text PDF