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The "man in barrel syndrome" is a condition which resembles the aspect of patient being constrained in a barrel in which patient presents with bilateral upper limb weakness. It has classically been attributed to supratentorial lesions in watershed zones. We present such a case in a 12-year-old child who presented with bibrachial weakness and was noted to have cervical cord infarct on imaging. Spinal cord infarct is a rare cause of this syndrome, and until now only 20 cases have been described in which cervical cord infarct led to this presentation, all of them being adults. We describe first case report of bibrachial diplegia due to cord infarct in a child. Our case adds to the limited literature of cervical cord ischemia as a cause of "(wo) man in barrel syndrome" and re-iterates the fact that imaging of cervical cord should be considered while evaluating these cases.
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http://dx.doi.org/10.1007/s00381-020-04927-6 | DOI Listing |
Cureus
July 2025
General Internal Medicine, King's Mill Hospital, Sherwood Forest Hospitals NHS Foundation Trust, Sutton-in-Ashfield, GBR.
A man in his 70s with known vascular risk factors presented with acute onset of bilateral lower limb weakness and urinary retention. Initial spinal magnetic resonance imaging (MRI) revealed a longitudinally extensive myelopathy. It was initially interpreted as transverse myelitis, prompting treatment with high-dose corticosteroids.
View Article and Find Full Text PDFCurr Issues Mol Biol
August 2025
1st Department of Obstetrics and Gynecology, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania.
Background: Inherited thrombophilia is increasingly recognized as a contributing factor to placental vascular pathology and adverse pregnancy outcomes. While the clinical implications are well-established, fewer studies have systematically explored the histopathological changes associated with specific genetic mutations in thrombophilic pregnancies.
Materials And Methods: This retrospective observational study included two cohorts of placental samples collected between September 2020 and September 2024 at a tertiary maternity hospital.
J Biomed Res
August 2025
Department of Pharmacy & Engineering Research Center of Tropical Medicine Innovation and Transformation, the First Affiliated Hospital & School of Pharmacy of Hainan Medical University, Haikou, Hainan 570102, China.
Ranked as the most prevalent cause of death worldwide, ischemic stroke urgently requires innovative therapeutic strategies. The present study demonstrates the therapeutic potential of human umbilical cord-derived mesenchymal stem cell-derived exosomes (hUMSC-Exos) in ameliorating hypoxia-induced cerebrovascular endothelial dysfunction through modulation of the AMPK/NLRP3 signaling pathway. Bioinformatics analysis of DisGeNET and exosomal cargo databases revealed 283 overlapping cerebral ischemia-related genes, implicating hUMSC-Exos in inflammatory regulation.
View Article and Find Full Text PDFNeuroreport
October 2025
Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Purpose Of The Research: This study aimed to explore the effects of exercise on sensorimotor recovery after stroke, neuroplasticity changes in the brain and spinal cord, and spinal cord compensation mechanisms.
Methods: A rat model of ischemic stroke was induced using the middle cerebral artery occlusion/reperfusion method. A T10 spinal cord injury (SCI) model was induced using a modified Allen procedure.
Front Cell Neurosci
August 2025
College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding, Hebei, China.
Background: Stroke is a leading global cause of disability and mortality, with ischemic stroke triggering NMDAR overactivation and excitotoxic neuronal injury. Extracellular vesicles (EVs) derived from stem cells under specific microenvironmental conditions show therapeutic potential for stroke recovery.
Materials And Methods: Photothrombotic stroke was induced in male ICR mice, followed by intravenous administration of EVs from memantine-preconditioned human umbilical cord mesenchymal stem cells (HUC-MSCs; M-EV).