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Ceftriaxone is a third-generation cephalosporin antibiotic that has been widely used to treat various infectious diseases. We report a case of ceftriaxone pseudolithiasis that was detected by computed tomography (CT) and followed up until it was resolved. A 76-year-old woman with diabetes mellitus and renal impairment, but no history of gallstones, was diagnosed with septic shock due to renal and lung abscesses and treated with ceftriaxone. On day 22 after admission, abdominal CT revealed a gallstone, which increased in size up to day 50. Ceftriaxone was stopped on day 50, and the gallstone resolved completely after 10 weeks. Ceftriaxone pseudolithiasis should be cautiously considered, specifically in a patient with renal impairment and a prolonged treatment period.
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http://dx.doi.org/10.2185/jrm.2020-020 | DOI Listing |
Eur J Microbiol Immunol (Bp)
August 2025
5Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, Hamburg, Germany.
Background: Ceftriaxone-induced biliary pseudolithiasis is a disease entity frequently observed in children, while it is rarely seen in adult patients. We provide a thorough sonographic workup of the case to guide sonographers confronted with it.
Case Report: A 41-years-old male patient with sonographically confirmed, culture-negative endocarditis accompanied by repeated fever episodes received 4g ceftriaxone per day next to ampicillin and gentamicin as an element of his antibiotic therapy.
Radiol Case Rep
August 2025
Department of Gastroenterology and Hepatology, Otemae Hospital, 1-5-34 Otemae, Chuo-ku, Osaka 540-0008, Japan.
A 73-year-old woman was hospitalized with fever and back pain. Ceftriaxone (2 g/day) was administered due to suspicion of bacterial infection. On hospital day 5, ceftriaxone was replaced with cefepime.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
June 2025
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Background: Ceftriaxone is believed to increase the risk of biliary infections due to pseudolithiasis caused by ceftriaxone-calcium precipitation, but this risk is not well understood. This study aimed to investigate whether ceftriaxone use is associated with an increased risk of biliary infections in pneumonia patients using a national inpatient database.
Methods: We analyzed the Diagnosis Procedure Combination database in Japan, identifying pneumonia patients between July 2010 and March 2022.
Front Pediatr
January 2025
Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Introduction: Ceftriaxone (CTX) is widely used in pediatric infectious disease treatment, although the diagnostic and therapeutic management of CTX-induced gallbladder pseudolithiasis (PL) remains challenging. In this study, we investigated the occurrence, clinical features, and management of CTX-induced PL in children.
Methods: A retrospective case-control study was conducted on 185 pediatric patients receiving CTX at a single center.
Front Med (Lausanne)
November 2024
Department of Gastroenterology, Ankang Central Hospital, Ankang, Shaanxi, China.
This paper reports a case of pseudolithiasis caused by the use of ceftriaxone sodium. The patient, a 54-year-old female, presented with intermittent abdominal pain and distension for 1 month. Initial ultrasonography showed no abnormalities.
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