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Objective: This study examined the impact of treating postpartum depression (PPD) with cognitive-behavioral therapy (CBT) on mother and infant behavior on the face-to-face still-face (FFSF) paradigm.
Methods: Data from 68 mothers and their infants, 35 women with PPD within 12 months of delivery, and 33 healthy control dyads matched on infant age, sex and familial socioeconomic status were examined. Women with PPD received nine weeks of group CBT and were compared with healthy control dyads with at three timepoints on changes in mother-infant performance on the FFSF.
Results: A significant group x FFSF phase x visit interaction was observed for infant withdrawn behavior at the three months post-treatment (p=0.006). Infants of mothers with PPD displayed significantly less withdrawn behavior after treatment, normalizing to levels of control infants.
Limitations: A relatively small sample consisting predominantly of Caucasian mother-infant dyads and the presence of comorbid anxiety in the PPD group.
Conclusion: Three months after group CBT for PPD, infants' withdrawn behavior appears to normalize to levels seen in the infants of healthy controls. Future studies should investigate whether treatments focused on the mother-infant dyad have distinctive effects on mothers and their infants' behaviors.
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http://dx.doi.org/10.1016/j.jad.2020.09.101 | DOI Listing |
Expert Opin Drug Discov
September 2025
First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Despite advances in antidepressant development, many patients with major depressive disorder (MDD) remain inadequately treated. Gepirone, a selective 5-HT1A agonist without reuptake inhibition, offers a novel mechanism potentially improving efficacy and tolerability over selective serotonin reuptake inhibitors (SSRIs) and earlier agents.
Areas Covered: This case history describes gepirone's discovery and development, including its pharmacodynamic profile, preclinical data on pharmacology, mechanism of action, and effects on depressive-like behavior and anxiety, as well as early clinical findings on its safety and efficacy in major depressive disorder.
ACS Appl Mater Interfaces
August 2025
Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China.
Three-dimensional deformation endows organisms with the capacity to autonomously process environmental stimuli. The transformation of plant tendrils from linear to spiral shapes has garnered considerable interest. Although many artificial soft actuators have been developed, fabricating a responsive spiral fiber resembling tendrils still remains a challenge.
View Article and Find Full Text PDFJ Affect Disord
August 2025
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia. Electronic address:
Depression and anxiety are highly prevalent mental health issues, impacting many parents. Research suggests that parents with depression and/or anxiety experience parenting difficulties, and their children have a higher risk of mental health issues. However, it is unclear whether and to what extent parents with and without depression and/or anxiety differ in specific parenting behaviours and attitudes.
View Article and Find Full Text PDFCochrane Evid Synth Methods
September 2025
Department of Epidemiology and Biostatistics University of Arizona Tucson AZ USA.
Background And Objectives: The relevance of Cochrane systematic reviews depends on timely completion and updates. This study aimed to empirically assess the lifecycles of Cochrane reviews published from 2003 to 2024, including transitions from protocol to review, update patterns, and withdrawals.
Methods: We extracted data from Cochrane Library publications between 2003 and 2024.
Eur Arch Psychiatry Clin Neurosci
August 2025
Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany.
Background: Despite the proven efficacy of antipsychotics in relapse prevention in schizophrenia and schizoaffective disorder, every third patient experiences a relapse within less than one year. Relapses can worsen psychosocial and treatment related outcomes and lead to substantial economic costs, primarily due to frequent and prolonged hospitalizations. The aim of this project is to evaluate a smartphone- and web-based digital solution for detecting early warning signs of schizophrenia and schizoaffective disorder to reduce relapses and subsequent hospitalizations.
View Article and Find Full Text PDF