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Aim: To validate a Japanese version of the Gastrointestinal Quality of Life Index (GIQLI) in patients with symptomatic gallstone disease.
Methods: We investigated responsiveness, reliability, and convergent validity of the translated GIQLI in patients who underwent elective laparoscopic cholecystectomy. Questionnaire scores were compared with the Gastrointestinal Symptom Rating Scale (GSRS) to verify convergent validity.
Results: There were 120 patients originally enrolled in the study; three were excluded after their surgery as they no longer met the inclusion criteria. Questionnaires were collected from the remaining 117 patients (100% response rate). At 2 weeks post-surgery, total GIQLI score increased significantly from pre-surgery levels, suggesting high responsiveness. Cronbach's alpha ranged from 0.901 to 0.934 for the total score, while a comparison of scores at 2 vs 6 weeks post-surgery yielded an intraclass correlation coefficient of 0.843; thus, the Japanese version of the questionnaire was reliable. Correlations with GSRS ranged between -0.459 and -0.679, indicating fair to good convergent validity.
Conclusion: The Japanese GIQLI had high responsiveness and reliability to assess how surgery for symptomatic gallstone disease influenced patient quality of life.
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http://dx.doi.org/10.1002/ags3.12376 | DOI Listing |
Front Hum Neurosci
August 2025
Faculty of Human Sciences, Waseda University, Tokorozawa, Japan.
Suppressing irrelevant information during problem-solving is vital. Misleading or unrelated information may hinder the performance. However, previous studies inferred suppression-related brain regions based on overall problem-solving or pre-solution neural activity, resulting in insufficient experimental control over the precise timing of suppression and the types of information requiring suppression.
View Article and Find Full Text PDFAging Clin Exp Res
September 2025
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Background: Intrinsic capacity (IC) and frailty are distinct but complementary frameworks for understanding the heterogeneity of aging. Although both have been linked to self-rated health, little is known about how their combined status relates to older adults’ health perceptions. This cross-sectional study investigated how combinations of IC and frailty status were associated with self-rated health among community-dwelling older adults.
View Article and Find Full Text PDFJ Dermatol
September 2025
Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan.
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in patients with advanced malignant melanoma (MM). However, more than half of patients receiving anti-programmed cell death protein-1 (PD-1) antibody monotherapy still fail to respond, with response rates varying by race and melanoma subtype. Additionally, immune-related adverse events (irAEs) remain a major concern.
View Article and Find Full Text PDFDrugs Aging
September 2025
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University (Ohashi Medical Center), Tokyo, Japan.
Interleukin (IL)-6 plays a central role in amplifying inflammation, and its inhibition is beneficial in managing immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis (RA). IL-6 signaling inhibition is associated with a slightly increased risk of infections in patients with RA, and older age has been identified as a risk factor for severe adverse events, including infections. Therefore, the combination of an aging population and the increasing use of IL-6R inhibitors in RA treatment highlights the importance of carefully evaluating the safety and effectiveness of these therapies in older patients with RA.
View Article and Find Full Text PDFAppl Neuropsychol Adult
September 2025
Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Tochigi, Japan.
Early detection is a critical issue in dementia prevention. This study utilizes intra-individual variability in reaction time (IIV-RT) as an indicator of cognitive function. By analyzing data over a one-year period, we examine the association between IIV-RT and the Japanese version of the Montreal Test of Cognitive Abilities (MoCA-J), a cognitive screening test.
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