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We report 2 cases of de novo renal cell carcinoma (RCC) in renal grafts after transplantation. Both patients underwent nephron sparing surgery (NSS) 211 and 167 months after transplantation, revealing papillary RCC with a tumour size >4 cm (pT1a). Within a follow-up of 25 and 32 months after NSS, a stable renal function without indication for dialysis was present. No recurrence of RCC in both cases was reported within the yearly routine examinations. NSS in kidney allografts is a safe procedure with preservation of renal function.
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http://dx.doi.org/10.1159/000509292 | DOI Listing |
Am J Kidney Dis
September 2025
Division of Kidney Disease and Hypertension, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:
The evaluation and management of renal masses, predominantly of the clear cell renal cell carcinoma subtype, have been evolving over the past several years and demanding greater attention from nephrologists. Oncologic survival of localized tumors approaches 100%, where survival is more closely tied to underlying comorbidities including chronic kidney disease (CKD). Early diagnosis and thus increasing prevalence related to incidental discovery of renal masses allows greater emphasis on nephron-sparing procedures and for residual kidney function preservation.
View Article and Find Full Text PDFJ Robot Surg
August 2025
Michigan Institute of Urology, 11051 Hall Road, Suite 220 , Utica, MI, 48317, USA.
Robotic partial nephrectomy (RPN) is a standard-of-care nephron-sparing intervention for clinical stage T1 renal masses (cT1RMs). We evaluated RPN outcomes performed using the da Vinci single port (SP) and multiport (Xi) platforms in a statewide quality improvement collaborative since SP introduction in Michigan. MUSIC-KIDNEY maintains a prospective registry of newly diagnosed cT1RM.
View Article and Find Full Text PDFBioengineering (Basel)
August 2025
Department of Pediatric Oncology Surgery, Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.
Wilms' tumor is a common pediatric renal malignancy. In selected cases, nephron-sparing surgery (NSS) may be employed as part of the surgical approach. To prevent positive margins, optimal understanding of the tumor-kidney edge is essential.
View Article and Find Full Text PDFCancers (Basel)
August 2025
Department of Urology, Humanitas Gavazzeni, 24125 Bergamo, Italy.
Objective: To evaluate the perioperative outcomes, functional impact, and oncologic efficacy of off-clamp robotic-assisted partial nephrectomy (RAPN) in patients with renal masses across multiple high-volume centers.
Materials And Methods: We conducted a retrospective multicenter study including 563 patients (group 1) who underwent clampless RAPN between January 2018 and December 2024. Patients with solitary kidneys, tumors >7 cm, or prior renal surgery were excluded.
Cent European J Urol
April 2025
Department of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Greece.
Introduction: Minimally-invasive partial nephrectomy (MIPN) is the standard treatment for kidney tumors with a diameter smaller than 4 cm. It is also performed in selected cases of tumors reaching 7 cm, but it may lead to potential complications. We investigated the current literature for simulators that could be used to teach urologists alone or within the boundaries of a course or a curriculum.
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