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http://dx.doi.org/10.1016/j.prrv.2020.08.006 | DOI Listing |
Ned Tijdschr Geneeskd
September 2025
LUMC, Leiden, afd. Psychiatrie.
Agitated patients present a challenge in clinical practice. Management strategies vary depending on severity, ranging from (non-)verbal de-escalation to pharmacological sedation. This article outlines a stepwise approach to treating agitation, distinguishing between mild, moderate, and extreme agitation.
View Article and Find Full Text PDFCancer Res Commun
September 2025
Spanish National Cancer Research Centre, Madrid, Madrid, Spain.
Purpose: Advanced, pre-treated TNBC has a dismal prognosis and lacks effective options beyond standard cytotoxics. We previously showed, via phosphoproteomic screening, that CDK6 and ERK hyperactivation are linked to adverse outcomes and represent actionable targets. This prompted us to evaluate palbociclib and binimetinib in advanced TNBC after one or two prior therapies.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Infected wound treatment remains a critical challenge in clinical medicine. Although existing treatments, like local debridement, antimicrobial agents, and growth factor therapies, have demonstrated certain therapeutic effects, they primarily target only specific stages of wound healing. Moreover, the escalating issue of antibiotic resistance limits their efficacy.
View Article and Find Full Text PDFAim To analyze the efficacy and cost-effectiveness of various options of antithrombotic therapy in patients with type 2 diabetes mellitus (T2DM) after acute coronary syndrome (ACS), based on the results of a one-year follow-up.Material and methods The article presents features of various antithrombotic therapies in patients with T2DM after ACS from the standpoint of efficacy and cost-effectiveness in real clinical practice based on the materials of the ORACLE II open prospective observational study (2014-2017). The data of 368 patients were divided into three groups based on the selected antithrombotic therapy.
View Article and Find Full Text PDFFront Physiol
August 2025
Department of Anorectal Surgery, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, China.
Background And Aims: Crohn's disease (CD) exhibits escalating incidence in China, particularly in coastal regions undergoing rapid industrialization. We aim to investigate the epidemiological characteristics of CD and identify factors influencing diagnostic delay in the Yancheng region of China.
Methods: A cross-sectional analysis was conducted on CD patients from two tertiary medical centers (Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine and Yancheng No.