Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
An amendment to this paper has been published and can be accessed via the original article.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495849 | PMC |
| http://dx.doi.org/10.1186/s12913-020-05714-4 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
UGT2B7-mediated drug-drug interaction between cannabinoids and hydromorphone.
Drug Metab Dispos
July 2025
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Division of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York
Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7 to form the inactive hydromorphone-3-glucuronide. Given that previous studies have shown that the major cannabinoids, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), inhibit several UGT enzymes, the objective of the present study was to determine the inhibitory potential of major cannabinoids and their metabolites on UGT-mediated hydromorphone metabolism.
View Article and Find Full Text PDFEfficacy and safety of intravenous sufentanil administration in low-severity acute trauma as a competence of paramedics: a follow-up observational study.
Eur J Trauma Emerg Surg
September 2025
Emergency Medical Services of Karlovy Vary Region, Zavodni 390/98C, Karlovy Vary, 36006, Czech Republic.
Background And Importance: In the Czech Republic, paramedics are required to consult a physician before administering intravenous opioids, which may delay effective prehospital pain management. As paramedic competencies expand in Europe, it is important to evaluate the safety and efficacy of independent opioid administration in prehospital emergency care settings.
Objectives: To assess the safety and effectiveness of intravenous sufentanil administered independently by trained paramedics compared to administration following remote physician consultation in adult trauma patients.
Mendelian randomization study: The association between pain, analgesics, and frailty.
Medicine (Baltimore)
September 2025
Department of Anesthesiology, Nan'an Hospital, Quanzhou City, China.
Pain, frailty, and the use of analgesic medications often occur together. Previous studies have demonstrated a strong link between them. The purpose of this study was to investigate the causal effects of pain and analgesic medication on frailty.
View Article and Find Full Text PDFSurgical treatment of hip dysplasia in cerebral palsy: A retrospective comparison between open and closed reduction.
Medicine (Baltimore)
September 2025
Department of Orthopedics and Traumatology, Brazilian Association for the Welfare of the Handicapped Children (AACD), São Paulo, SP, Brazil.
Hip dysplasia in cerebral palsy (CP) is a common and severe problem, especially among nonambulatory patients. A likely cause is muscular imbalance and developmental bone changes leading to a progressive extrusion of the femoral head from the acetabulum. The ideal surgical treatment aims to reduce the dislocated hip to improve pain, positioning, and function.
View Article and Find Full Text PDFBlue velvet - Pseudocyanosis, a rare case of drug-induced bluish hyperpigmentation with clozapine: A case report.
Medicine (Baltimore)
September 2025
Division of General Internal Medicine, Department of Medicine, University Hospitals, Genève, Switzerland.
Rationale: This case highlights the importance of considering a wide range of possible diagnoses when faced with unexplained hemorrhagic symptoms. When standard investigations fail to identify a clear cause, it is essential to conduct a detailed dietary history. This can lead to the diagnosis of scurvy, a reversible vitamin C deficiency that is often overlooked in populations at risk.
View Article and Find Full Text PDF