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Purpose: Rolling resistance is a drag force that increases the required propulsion force of manual wheelchair users (MWU) and increases the risk of upper extremity pain and injury.
Materials And Methods: To understand the influence of different design, environmental, and setup factors on rolling resistance (RR), a series of tests were performed on a range of wheels and casters using a drum-based equipment with the capability to measure RR forces. Independent factors were varied including load, camber, toe, speed, tire pressure, and surface, using ranges anticipated in the community. Combined factor testing of these factors was also completed to evaluate of RR changes due interactions of multiple factors.
Results: A default reference trial was used to verify repeatability throughout the 924 rear wheel trials and 255 caster trials. Toe angle and tire pressure were found to have large and exponential relationships to RR. Tire/caster type and surfaces are significant influencers but have no specific relationship to RR. Load had a direct linear relationship to RR whereas camber and speed had a relatively small impact on RR. Pneumatic tires had lower rolling resistance compared to airless inserts, solid mag wheels and knobby tires. Combined factor testing revealed a linear additive effect of individual factors. Statistical analysis revealed that tire/caster type is a covariate to all of the results and statistical differences ( < 0.01) were found for toe, tire/caster type, tire pressure, surfaces and load.
Conclusions: Factors act in a cumulative manner to impact RR and need to be monitored in device design, development, issuance, and maintenance.Implications for RehabilitationFirst comprehensive study of MWC RR showing the effects of individual and combined factors.Highlights the direct importance of tire and caster selection.
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http://dx.doi.org/10.1080/17483107.2020.1815088 | DOI Listing |
J Rehabil Assist Technol Eng
September 2025
Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA, USA.
Minimizing repetitive strain (RS) is a key recommendation from clinical practice guidelines for preservation of upper limb. Propulsion force, which is required to overcome wheel rolling resistance (RR), is a major source of RS. A drum-based RR test method has been developed but has not been directly validated against propulsion forces.
View Article and Find Full Text PDFRSC Adv
September 2025
State Key Laboratory of Disaster Prevention & Reduction for Power Grid Changsha China
Positive temperature coefficient (PTC) materials are pivotal for safeguarding lithium iron phosphate batteries, yet their industrial application is hindered by critical drawbacks: excessive film thickness, high internal resistance, and poor solvent sustainability. Addressing these challenges, this study innovatively develops a solvent-free thermal rolling process to fabricate an asymmetric expansion polymer film, specifically thermoplastic polyurethane (TPU) reinforced polyethylene (PE)/carbon composites, which significantly enhances the PTC effect. The core mechanism lies in the asymmetric thermal expansion of TPU and PE: this unique behavior disrupts the conductive carbon network, triggering a sharp PTC transition at around 120 °C.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610065, China.
Detection methods with single-nucleotide specificity are essential tools for nucleic acid analysis in diverse clinical and biological settings. However, both hybridization-based and enzyme-based methods are only effective for discriminating single-nucleotide mutations at certain positions, making it difficult to detect nucleic acid targets having multiple nearby mutations. Herein, we describe the design of cooperative recognition probes (CRPs) that integrate both hybridization and ligation-based recognition mechanisms and thus are highly effective for discriminating mutations throughout all positions.
View Article and Find Full Text PDFBackground: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital with COVID-19.
Methods: Patients admitted with COVID-19 pneumonia to 107 UK hospitals were randomly assigned (1:1) to either usual care alone or usual care plus a single 1 g infusion of sotrovimab, using web-based unstratified randomisation.
JAC Antimicrob Resist
April 2025
Department of Paediatric Infectious Diseases and Immunology, Southampton Children's Hospital, Southampton, UK.
Objectives: To improve antimicrobial stewardship (AMS) and reduce unnecessary antibiotic prescriptions in young children in a British primary care setting.
Methods: Forty-nine general practices in the South of England each hosted a 1 h in-house workshop, facilitated by trained local pharmacy professionals. This type of educational outreach approach using TARGET (Target Antibiotics Responsibly, Guidance, Education and Tools) antibiotic materials has previously been shown to reduce antibiotic dispensing in a UK primary care setting.