98%
921
2 minutes
20
Lineshape analysis is a recurrent and often computationally intensive task in optics, even more so for multiple peaks in the presence of noise. We demonstrate an algorithm which takes advantage of peak multiplicity (N) to retrieve line shape information. The method is exemplified via analysis of Lorentzian and Gaussian contributions to individual lineshapes for a practical spectroscopic measurement, and benefits from a linear increase in sensitivity with the number N. The robustness of the method and its benefits in terms of noise reduction and order of magnitude improvement in run-time performance are discussed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1364/OE.395877 | DOI Listing |
ACS Meas Sci Au
August 2025
Research Institute for Marine Geodynamics, Japan Agency for Marine-Earth Science and Technology, Yokosuka 237-0061, Japan.
High-precision measurement of peak parameters such as intensity (), peak position (ω ), full width at half-maximum (Γ), and area () is pivotally important for advancing scientific research. Achieving high-precision requires elucidating the physical principles governing measurement precision and establishing guidelines for optimizing analytical conditions. Although the pseudo-Voigt profile is a widely used line-shape model, the underlying principles governing the precision of its parameter estimation remained unclear.
View Article and Find Full Text PDFImaging Neurosci (Camb)
January 2025
Centre for Human Brain Health and School of Psychology, University of Birmingham, Birmingham, United Kingdom.
Functional MRS (fMRS) is a technique used to measure metabolic changes in response to increased neuronal activity, providing unique insights into neurotransmitter dynamics and neuroenergetics. In this study, we investigate the response of lactate and glutamate levels in the motor cortex during a sustained motor task using conventional spectral fitting and explore the use of a novel analysis approach based on the application of linear modelling directly to the spectro-temporal fMRS data. fMRS data were acquired at a field strength of 3 Tesla from 23 healthy participants using a short echo-time (28 ms) semi-LASER sequence.
View Article and Find Full Text PDFAnal Chim Acta
September 2025
Division of Instrumental Analytics (F.B. 1.3), Federal Institute for Materials Research and Testing (BAM), Berlin, D-12489, Germany. Electronic address:
Isotope ratio determination of lithium is increasingly important in fields ranging from geochemistry to battery diagnostics. While mass spectrometry remains the gold standard, it is costly, cumbersome, and incompatible with portable or inline implementations. Optical emission spectroscopy presents an appealing alternative.
View Article and Find Full Text PDFAnal Chem
July 2025
Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Banacha 2, Warsaw 02-097, Poland.
Nuclear magnetic resonance spectroscopy (NMR) is one of the most potent analytical chemistry methods, providing unique insight into molecular structures. Its noninvasiveness makes it a perfect tool for monitoring chemical reactions and determining their products and kinetics. Typically, the reactions are monitored by a series of H NMR spectra acquired at regular time intervals.
View Article and Find Full Text PDFNuclear magnetic resonance (NMR) spectroscopy is a powerful technique for protein structure determination, but traditional approaches require extensive manual assignment of hundreds to thousands of resonances. Here we present NMRFAM-BPHON, a novel "top-down" approach that treats experimental NMR spectra as continuous grayscale images and quantitatively scores the agreement with simulated spectra generated from candidate protein structures. This method does not require complete resonance assignments, though it can incorporate experimental chemical shifts when available to improve performance.
View Article and Find Full Text PDF