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Invited for the cover of this issue is Christopher Bejger and co-workers at UNC Charlotte, Columbia University, and Donghua University. The image depicts a pair of star clusters in the constellation Perseus as the structure of two metal clusters in the reported framework. Read the full text of the article at 10.1002/chem.20201215.
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http://dx.doi.org/10.1002/chem.202003061 | DOI Listing |
New Phytol
September 2025
State Key Laboratory of Plant Diversity and Specialty Crops/Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
Heterostyly is a polymorphic floral adaptation controlled by supergenes. The molecular basis of distyly has been investigated in diploid species from several unrelated families, but information is lacking for polyploid systems. Here, we address this knowledge gap in Schizomussaenda henryi, a tetraploid distylous species of Rubiaceae, the family with the greatest number of heterostylous species.
View Article and Find Full Text PDFUnlabelled: Kaposi's sarcoma-associated herpesvirus (KSHV) orchestrates late gene transcription through viral transcriptional activators that hijack host RNA polymerase II machinery, maintaining selectivity for viral promoters. Among these, the KSHV protein ORF24 serves as a TATA-binding protein (TBP) mimic essential for recognizing viral late promoters, although the molecular mechanisms underlying its function remain poorly characterized. Here, we used AlphaFold3 to predict the structure of ORF24 in complex with DNA and validated key features in both transfected cells and during KSHV lytic replication.
View Article and Find Full Text PDFFront Plant Sci
August 2025
College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, SK, Canada.
This article presents a novel perspective on plant embryogenesis, fundamentally differentiating it from the animal embryo model upon which plant models have long been based to discern the genetic and molecular mechanisms. We propose a plant embryonic body plan that aligns developmental and evolutionary insights across all five embryophyte groups (bryophytes, lycophytes, monilophytes, gymnosperms, and angiosperms). This conceptual model is grounded in a Reprogramming Potential (RP) involving an activation (RP1+) -suppression (RP1-) switch (RP1+/RP1-), which integrates embryonic development in a stepwise manner across diverse embryophytes.
View Article and Find Full Text PDFFront Microbiol
August 2025
Department of Microbiology, Graduate School of Medicine, Tokushima University, Tokushima, Japan.
The virion assembly represents a critical aspect of producing infectious progenies required for HIV-1 replication. Each step in that process, such as Gag-membrane binding, Gag-genomic RNA binding/packaging, Gag multimerization, and viral particle budding, has been extensively analyzed in a stepwise and specific manner. While Gag proteins are the primary drivers of HIV-1 virion assembly, the interactions between Gag and RNA play a significant role in regulating the process.
View Article and Find Full Text PDFJHEP Rep
September 2025
Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China.
Background & Aims: HBV integration profiles in the natural history of chronic HBV infection (CHB) have not been well-defined. Hence, we aimed to determine HBV integration profiles across different CHB phases.
Methods: We delineated integration profiles from liver biopsies of 55 patients in different CHB phases (3 HBsAg-positive/HBeAg-positive infection; 13 HBsAg-positive/HBeAg-positive hepatitis; 7 HBsAg-positive/HBeAg-negative infection; 12 HBsAg-positive/HBeAg-negative hepatitis; 10 HBsAg seroclearance; 10 occult HBV).