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http://dx.doi.org/10.1001/jama.2020.9216 | DOI Listing |
IEEE J Biomed Health Inform
September 2025
This study aims to optimize the dynamic administration regimen of prophylactic enoxaparin in critically ill patients to reduce the risk of VTE, major bleeding, and 30-day all-cause mortality. We developed and internally and externally validated an artificial intelligence (AI) policy utilizing Double dueling deep Q network, using data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database (training and internal test set) and the eICU Collaborative Research Database (eICU-CRD, external test set). We compared the performance among the AI policy, the clinician's policy, the weight-tiered policy, and the fixed 40- mg-once-daily (QD) policy.
View Article and Find Full Text PDFCardiol Rev
September 2025
Departments of Cardiology and Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY.
Sepsis remains a leading cause of critical illness and mortality worldwide, driven by a dysregulated host response to infection and often complicated by persistent tachycardia and cardiovascular dysfunction. Increasing evidence implicates excessive sympathetic activation as a contributor to sepsis-related hemodynamic instability and myocardial injury, prompting growing interest in the use of β-adrenergic blockade as a therapeutic adjunct. This review synthesizes current data on the safety and efficacy of short-acting, cardioselective β-blockers (BBs), particularly esmolol and landiolol, in septic shock.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Background: Acetaminophen, a widely used analgesic, has drawn attention for its potential to reduce oxidative stress through inhibiting lipid peroxidation and scavenging free radicals. Emerging evidence indicates that early acetaminophen administration might improve survival outcomes in surgical intensive care unit (SICU) patients. This study aims to explore the relationship between early acetaminophen use and mortality in this patient population.
View Article and Find Full Text PDFJ Spinal Cord Med
September 2025
Department of Surgery, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
Study Design: A retrospective study with a crossover design.
Objectives: Maintaining mean arterial pressure (MAP) is crucial in the early management of SCI, yet the role of oral midodrine in this setting remains unclear. This study evaluates whether midodrine facilitates IV vasopressor weaning within 24 hours of initiation.
J Am Coll Surg
September 2025
Division of Trauma/Surgical Critical Care, University of Tennessee Health Science Center, Memphis, Tennessee.
Background: Gastrointestinal bleeding (GiB) is associated with hypoperfusion, cytokine release, and alterations to the mucosal barrier frequently seen in the critical care population. Risk factors in the population at large have been well-studied, but few have specifically addressed the unique circumstances surrounding critically ill trauma patients. We aimed to evaluate the incidence and risk factors for GiB in the trauma critical care population.
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