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Article Abstract
Objective: To compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm.
Study Design: Sub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples.
Results: Plasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland-Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: -4.1, 15.9 pg/mL).
Conclusions: We found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm.
Implications: Our data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232040 | PMC |
| http://dx.doi.org/10.1016/j.contraception.2020.08.011 | DOI Listing |
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Article Synopsis
- This study aimed to compare how different laboratories measure etonogestrel, a contraceptive hormone, focusing on accuracy and precision across six labs (five academic and one commercial).
- In tests with prepared serum and plasma samples, four labs achieved accurate results within ±15% of expected concentrations, while high precision was demonstrated, with minimal variation across results.
- However, while individual labs generally correlated well with a reference lab for serum samples, some showed biases resulting in consistently higher or lower readings, highlighting variability in etonogestrel measurement methods across different facilities.