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Asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carriage among hospitalized children and risk of transmission to healthcare workers (HCWs) was evaluated by point prevalence survey. We estimated 1-2% prevalence of SARS-CoV-2 among children without coronavirus disease 2019 symptoms. There was no secondary transmission among HCWs exposed to these patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499659 | PMC |
http://dx.doi.org/10.1093/jpids/piaa102 | DOI Listing |
Pediatr Blood Cancer
September 2025
Acute Myeloid Leukemia Sub-Committee, Association of Childhood Leukemia Study (JACLS), Japan.
Background: Relapsed or refractory cases of pediatric acute myeloid leukemia (AML) have poor outcomes despite advancements in chemotherapy and hematopoietic stem cell transplantation (HSCT). While a second HSCT is often a salvage option, its outcomes vary widely, and prognostic factors remain unclear.
Objectives: This study aimed to evaluate outcomes and identify prognostic factors in pediatric patients with AML who underwent multiple HSCTs.
Semin Dial
September 2025
Department of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Background: In hyponatremic patients, concurrent dialysate flow during hemodialysis may be an ideal option to mitigate complications such as osmotic demyelination syndrome (ODS).
Methods: Present randomized controlled trial enrolled dialysis-requiring chronic kidney disease (CKD) and acute kidney injury (AKI) patients with serum sodium levels < 125 mEq/L during January 2020 over 16 months. Hemodynamically unstable patients, as well as those with a history of seizures and neurological conditions, were excluded.
Neurol Med Chir (Tokyo)
September 2025
Department of Neurosurgery, Kurume University School of Medicine.
Currently, there is no effective treatment for elevated intracranial pressure in the acute phase of subarachnoid hemorrhage. Recently, we developed "step-down infusion of barbiturate," a therapeutic strategy for severe traumatic brain injury, which decreased intracranial pressure and significantly reduced mortality without serious side effects. This study aimed to examine the efficacy of step-down infusion of barbiturate in patients with severe subarachnoid hemorrhage.
View Article and Find Full Text PDFBest Pract Res Clin Endocrinol Metab
August 2025
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel 4031, Switzerland; Department of Clinical Research, University Hospital Basel, University of Basel, Basel 4031, Switzerland; Department of Endocrinology and Diabetes, Cantonal Hospital Baselland, Switzerland. E
Chronic hyponatremia is increasingly recognized as a potential contributor to impaired bone health, although the underlying pathophysiological mechanisms have not yet been fully elucidated. Experimental studies have demonstrated that low serum sodium levels affect both osteoclast and osteoblast function, resulting primarily in increased bone resorption and secondarily in reduced bone formation. In humans, however, evidence regarding the effects of hyponatremia on bone remains limited.
View Article and Find Full Text PDFWorld Neurosurg
September 2025
Department of Spinal Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. Electronic address:
Background: Spinal cord perfusion impairment is a critical secondary mechanism in acute spinal cord injury (SCI). Although lumbar cerebrospinal fluid (CSF) drainage is widely used in cardiothoracic surgery, its use in SCI remains limited. This study presents an evaluation of the safety and feasibility of lumbar CSF drainage with intrathecal pressure (ITP) and spinal cord perfusion pressure (SCPP) monitoring in acute SCI patients.
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