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Surgeon-dependent factors such as optimal implant alignment of the tibial component are thought to play a significant role in the outcome following primary total knee arthroplasty (TKA). In addition, tibial component malrotation is associated with pain, stiffness, and altered patellofemoral kinematics in TKA. However, measuring tibial component rotation after TKA is difficult. Therefore, the purpose of this study was to find a reliable method for positioning the tibial component in TKA. To investigate the morphology of the tibial plateau, 977 patients' knees (829 females and 148 males) were evaluated using MRI. The relationships between the femoral transepicondylar axis (TEA), Akagi line, posterior tibial margin (PTM), medial third of the tibial tubercle (MTT), and anatomical tibial axis (ATS) were investigated in this study. In addition, gender difference in tibial rotational alignment were evaluated. Relative to the TEA, the MTT and ATS were externally rotated by 0.5° ± 4.4° and 0.5° ± 5.4°, respectively, while Akagi line and PTM were internally rotated by 3.7° ± 4.5° and 9.9° ± 6.1°, respectively. Gender differences were found in MTT, Akagi line and ATS (P < 0.05). Our result showed that the rotational alignment led to notable variance between femoral and tibial components using fixed bone landmarks. The MTT and ATS axes showed the closest perpendicular aspect with projected TEA. And the MTT and Akagi axes showed the reduced variance. In addition, PTM is not a reliable landmark for rotation of the tibial component. Based on the results of this study, surgeons may choose the proper anteroposterior axis of the tibial component in order to reduce rotational mismatch and improve clinical outcomes.
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http://dx.doi.org/10.1038/s41598-020-70851-z | DOI Listing |
J Am Podiatr Med Assoc
September 2025
§Aybars Kıvrak Orthopedics Clinic, Adana, Turkey.
Background: Pilon fractures refer to distal tibial fractures that may involve extra-articular, partial articular, or complete intra-articular components, most commonly caused by high-energy trauma. The choice between early (<72 hours) and delayed (>7 days) surgical fixation significantly impacts clinical outcomes. This study aimed to compare the effects of early vs.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
September 2025
Department of Orthopaedic Surgery and Traumatology, Ghent University, Ghent, Belgium.
Purpose: Robot-assisted total knee arthroplasty (RATKA) aims to improve surgical precision and outcomes. This study compared clinical and radiological outcomes between RATKA and conventional total knee arthroplasty (CTKA).
Methods: A systematic review was conducted in accordance with PRISMA guidelines, including prospective studies (Level I/II evidence) from MEDLINE, Embase, Web of Science, and the Cochrane Library, up to 20 May 2025.
Int J Numer Method Biomed Eng
September 2025
Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran.
The need for total knee arthroplasty (TKA) has grown significantly in recent years. The cutting angle in TKA plays a major role in the functionality and life expectancy of the knee implant components. This study aims to personalize the femur bone cutting angle selection for implant placement.
View Article and Find Full Text PDFPurpose: Knee osteoarthritis (OA) is the most common degenerative joint disease in the world. It results in not only physical limitation and pain, but also negatively impacts quality of life and mental wellbeing. Treatment options such as medial opening wedge high tibial osteotomy (MOWHTO) help to relieve pain and improve functionality, but there is limited literature on the effect on mental health.
View Article and Find Full Text PDFFASEB J
September 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Restenosis following endovascular intervention in lower extremity arterial disease contributes to significant morbidity and mortality. This study investigates the role of formylpeptide receptor 2 (FPR2) in neointimal hyperplasia and evaluates the therapeutic potential of the selective FPR2 agonist BMS-986235 in mitigating restenosis. FPR2 expression was significantly reduced in the popliteal and anterior tibial arteries of male amputees with restenosis compared to healthy controls.
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