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Objectives: Individuals with stroke often experience contralesional and ipsilesional arm motor deficits. The aim of this study was to compare fine and gross motor hand dexterity of the ipsilesional hand post-stroke with controls, normative values, and the contralesional hand.
Design: Data were collected from right-handed individuals with chronic stroke (n = 20), age-/sex-matched controls (n = 10), and normative values (n = 20) performing the Nine-Hole Peg Test and the Box and Blocks Test.
Results: Individuals with stroke demonstrated poorer performance with the ipsilesional arm relative to both the control group (mean difference [95% confidence interval]: Nine-Hole Peg Test [seconds], 3.4 [-0.5 to 7.3]; Box and Blocks Test [number of blocks], -12.3 [-20.3 to -4.2]) and normative values (mean difference [95% confidence interval]: Nine-Hole Peg Test [seconds], 6.5 [4.0-9.1]; Box and Blocks Test (number of blocks), -15.3 [-20.1 to -10.5]). Ipsilesional arm performance was significantly better than performance with the contralesional arm (mean difference [95% confidence interval]: Nine-Hole Peg Test [seconds], -9.4 [-20.2 to 1.4]; Box and Blocks Test (number of blocks), 33.2 [20.9-45.5]).
Conclusion: These findings identify residual deficits in fine and gross dexterity of the ipsilesional hand in commonly used outcome measures of hand manipulation among individuals with chronic stroke. Possible underlying mechanisms and clinical relevance are discussed.
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http://dx.doi.org/10.1097/PHM.0000000000001569 | DOI Listing |
Mov Disord
September 2025
Division Translational Genomics of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.
Background: Digital-motor outcomes promise better responsiveness than clinician-reported outcomes in ataxia trials. However, their patient meaningfulness and sensitivity to change remain to be demonstrated, particularly in the upper limb domain.
Objectives: Validation of quantitative motor (Q-Motor) assessment for upper limb ataxia against patient-reported outcomes and regarding sensitivity to both longitudinal and treatment-induced change, the latter in n-of-1 treatment settings.
J Neurosci Methods
August 2025
Department of Radiology, University of Calgary, AB, Canada; Hotchkiss Brain Institute, University of Calgary, AB, Canada; Department of Clinical Neurosciences, University of Calgary, AB, Canada. Electronic address:
Background: Multiple sclerosis (MS) causes diverse functional impairments that require early accurate characterization, but pertinent methods are scarce. This study aimed to develop new imaging-driven approaches for predicting MS functions.
New Method: 19 women with MS [10 relapsing-remitting (RRMS) and 9 secondary progressive (SPMS) subtypes] and 19 matched controls were examined including 3 T imaging.
Sensors (Basel)
August 2025
Neurology Unit, Galliera Hospital, 16149 Genova, Italy.
Upper limb (UL) impairment after stroke negatively influences stroke survivors' quality of life (QOL). This study aims to evaluate, through clinical assessment and accelerometric measures, the efficacy of anodal Transcranial Direct Current Stimulation (a-tDCS) combined with the Graded Repetitive Arm Supplementary Program (GRASP) in post-acute stroke UL rehabilitation. Subjects were enrolled if they were aged ≥18 years and had a first stroke diagnosis, UL motor impairment and adequate trunk control.
View Article and Find Full Text PDFNeurol Int
July 2025
Department of Neurology, Medical School, University of Pécs, 7623 Pécs, Hungary.
Introduction: Myotonia is a rare neuromuscular condition characterized by impaired muscle relaxation. In this study, we provide normative values for clinical tests related to myotonia in the Hungarian population and compare them to patients with myotonic dystrophy type 1 (DM1).
Methods: Relaxation tests (10 eye openings, tongue extension, and palm openings), handgrip strength, and the nine-hole peg test were conducted on 139 healthy individuals and 31 patients with DM1.
BMC Med Educ
August 2025
Department of Ophthalmology, Medical Faculty Hospital, Selcuk University, E block 2nd floor, Konya, Selcuklu, 42130, Turkey.
Purpose: Simulation technologies have advanced surgical education by enhancing motor skills, hand-eye coordination, and sensory acuity. This study examines correlations between sensory-motor skills and surgical simulator performance.
Methods: The cross-sectional and observational study included fifty medical doctors without surgical experience.