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Article Abstract
An efficient construction of imidazole ring by a CsCO-promoted annulation of amidoximes with terminal alkynes in DMSO has been developed. This protocol provides a simple synthetic route with high atom-utilization for the synthesis of 2,4-disubstituted imidazoles in good yields under transition-metal-free and ligand-free conditions. Internal alkynes can also undergo the annulation to give 2,4,5-trisubstituted imidazoles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463794 | PMC |
| http://dx.doi.org/10.3390/molecules25163621 | DOI Listing |
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