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Article Abstract
serogroup O25b-sequence type 131 ( O25b/ST131) is known as a multidrug-resistant organism with high virulence potential and has received attention internationally. We aim to investigate the prevalence of O25b/ST131 and the distribution of , pathogenicity island (PAI) markers, phylogenetic groups, and H-antigen typing in the O25b/ST131 isolated from patients with urinary tract infection (UTI) in Tehran, the capital of Iran. Seventy (26.9%) isolates were identified as O25b/ST131. There was also a significant difference in the prevalence of virulence genes, including , , , , , , and , in the O25b/ST131 isolates rather than non-O25b/ST131 ones ( 0.05). Furthermore, 78% of the O25b/ST131 isolates carried four to seven PAIs, while 71% of non-O25b/ST131 isolates carried two to four PAI markers ( 0.05). Our study showed that in addition to H4, other H-antigens may play a role in the O25b/ST131 virulence potential. Besides, a significant association was found between the history of previous UTIs and infection among the O25b/ST131 clone isolates. Pulsed-field gel electrophoresis revealed circulating of O25b:H4-ST131/PST43 clone in both hospital and community. Approximately one in every three uropathogenic isolates was the O25b/ST131 clone, representing a significant public health threat. Practical investigation on O25b/ST131 can be helpful in better understanding of ST131 evolution and controlling UTI in hospitals.
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Article Synopsis
- Urinary tract infections (UTIs) in children caused by E.coli, especially the O25b/ST131 strain, are concerning due to their increased virulence and resistance to antibiotics.
- A study analyzed 200 E.coli isolates from UTI cases in pediatric patients to assess their antimicrobial resistance, virulence factors, and phylogenetic groupings, aiming to improve UTI management strategies.
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