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http://dx.doi.org/10.1016/j.biopsych.2020.05.028 | DOI Listing |
Epilepsy Behav
September 2025
Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Einstein Center for Neurosciences (ECN), Charité - Universitätsmedizin Berlin, Germany. Electronic address:
Reactive astrogliosis and microgliosis are hallmarks of various central nervous system (CNS) diseases, including epilepsy. Both are observed following seizures in various models of epilepsy. We conducted a systematic meta-analysis to synthesize current knowledge on reactive astrogliosis and microgliosis in animal models involving experimentally induced seizures using a multilevel approach to analyze 260 comparisons from 52 studies.
View Article and Find Full Text PDFJ Neurooncol
August 2025
Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA.
Background: Patients with brain cancers are diagnosed based on MRI in the clinical setting while molecular signatures offer potential therapeutic targets. The necessity to re-form molecular and imaging information motivated our meta-analysis to decipher the correlation between the MRI-classified tumor locations, gene expression, and protein signatures in GBM.
Methods: We analyzed spatial and omics data alongside the assessment of post-translational modifications.
J Mol Neurosci
August 2025
Central Research Laboratory, NITTE (Deemed to Be University), KS Hegde Medical Academy (KSHEMA), Deralakatte, Mangalore, 575018, Karnataka, India.
Background: Neuroinvasive pathogens are capable of breaching the blood-brain barrier (BBB), and causing central nervous system infections. Although the response of human brain microvascular endothelial cells (hBMECs), the forefront cells of BBB has been extensively studied, the roles of astrocytes and pericytes in modulating BBB integrity during infection remain less defined.
Aims: The study aims for a meta-analysis of RNA-seq data to compare the transcriptional response of hBMECs alone and in co-culture with astrocytes and pericytes (BBB-spheroids) following infection with Neisseria meningitidis and Borrelia bavariensis.
Neurology
September 2025
Department of Neurology, Jackson Memorial Hospital, Miami, FL.
Background And Objectives: Outcome prediction in traumatic brain injury (TBI) guides treatment decisions. Biomarkers such as S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) have shown prognostication value, but relative effectiveness is unknown. This network meta-analysis (NMA) explored the relative predictive value of these 4 biomarkers for mortality and functional outcomes after moderate/severe TBI.
View Article and Find Full Text PDFACS Chem Neurosci
August 2025
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, 10 Akademika Lavrent'yeva Prospekt, Novosibirsk 630090, Russia.
Depression and post-traumatic stress disorder (PTSD) are treatment-resistant neuropsychiatric conditions closely linked to chronic neuroinflammation. Given the limitations of current pharmacotherapies, selective cyclooxygenase-2 (COX-2) inhibitors have emerged as promising candidates for modulating neuroimmune and oxidative pathways. This systematic review evaluated the efficacy of selective COX-2 inhibitors in improving behavioral and neuroinflammatory outcomes in rodent models of chronic stress or systemic inflammation relevant to depression and PTSD.
View Article and Find Full Text PDF