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Purpose: To test the hypothesis that the anatomic correlate of the gray optic disc crescent is pigmentation of externally oblique border tissue of Elschnig.
Design: Retrospective study.
Participants: African-American adult men with or without clinically apparent gray optic disc crescents.
Methods: McNemar's test for paired data and kappa statistic with 95% confidence intervals were used to examine the relationships between eyes with or without gray optic disc crescents and corresponding spectral-domain (SD) OCT images with enhanced depth imaging (EDI).
Main Outcome Measures: Correlation between clinical gray optic disc crescents and hyperreflectivity of externally oblique border tissue of Elschnig by SD OCT with EDI.
Results: Twenty-five eyes had clinically apparent gray optic disc crescents, of which SD OCT with EDI revealed hyperreflectivity (interpreted as increased pigmentation) of externally oblique (obtuse angle) border tissue of Elschnig in 22 eyes, that is, extending into Bruch's membrane opening and presumably visible by funduscopy. Thirty-two eyes from matched participants had no apparent gray optic disc crescent, of which SD OCT with EDI revealed hyperreflectivity of the border tissue of Elschnig in 23 eyes, but with a nonoblique (right angle) or internal (acute angle) angle, which would presumably obstruct funduscopic visualization.
Conclusions: Observations by SD OCT with EDI suggest that the anatomic correlate of the gray optic disc crescent is pigmentation of externally oblique border tissue of Elschnig.
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http://dx.doi.org/10.1016/j.ogla.2018.11.005 | DOI Listing |
Int Forum Allergy Rhinol
September 2025
Department of Otolaryngology, University of California Irvine, Irvine, California, USA.
The goal of this American Rhinologic Society expert practice statement (EPS) is to summarize the best available evidence for surveillance strategies following definitive treatment of sinonasal malignancy. Topics discussed include components of surveillance, including endoscopy and imaging subtypes, frequency and length of surveillance, and highlights of some specific pathologies that warrant special consideration. This EPS was developed following the recommended methodology and approval process as previously outlined.
View Article and Find Full Text PDFJ Med Eng Technol
September 2025
Department of Computer Engineering and Information Technology, Faculty of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran.
Diabetic retinopathy is a chronic and progressive eye disease in which the human retina is affected by an increase in the amount of insulin in the blood. Diabetic retinopathy, if not detected and treated in time, threatens the patient's vision and eventually causes complete blindness. Among various clinical symptoms, microaneurysm appears as the first sign of diabetic retinopathy.
View Article and Find Full Text PDFR Soc Open Sci
September 2025
Research Center for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of Chin
Hypertension is the primary cause of cardiovascular diseases, and its worldwide prevalence has continued to increase recently. Aortic fibre remodelling is critical in the development of hypertension and is strikingly age-related. However, the underlying microlevel variations remain unknown.
View Article and Find Full Text PDFCureus
August 2025
Department of Neurology, Tokyo Women's Medical University, Tokyo, JPN.
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a demyelinating disease of the central nervous system (CNS) that manifests as optic neuritis, transverse myelitis, acute disseminated encephalomyelitis, and cortical encephalitis. Some patients with MOGAD present with tumor-like brain lesions. However, hydrocephalus as an initial presentation is rare.
View Article and Find Full Text PDFBr J Ophthalmol
September 2025
Ophthalmology Institute, Assuta Medical Centers, Tel Aviv, Israel.
Background/aims: Reports have suggested that treatment with systemic β-adrenoceptor antagonists (β-blockers) may increase the risk of developing Parkinson's disease (PD). The objective of this study was to assess the association between the use of topical β-blockers and PD.
Methods: A retrospective cohort study.