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An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.
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http://dx.doi.org/10.1039/d0cc00494d | DOI Listing |
Stem Cell Rev Rep
September 2025
Paris Cité University, INSERM UMR-S 970, Paris Cardiovascular Research Centre, Paris, France.
Endothelial Colony-Forming Cells (ECFCs) are recognized as key vasculogenic progenitors in humans and serve as valuable liquid biopsies for diagnosing and studying vascular disorders. In a groundbreaking study, Anceschi et al. present a novel, integrative strategy that combines ECFCs loaded with gold nanorods (AuNRs) to enhance tumor radiosensitization through localized hyperthermia.
View Article and Find Full Text PDFBehav Res Methods
September 2025
Czech Technical University in Prague, Faculty of Electrical Engineering, Department of Cybernetics, Prague, Czech Republic.
Automatic markerless estimation of infant posture and motion from ordinary videos carries great potential for movement studies "in the wild", facilitating understanding of motor development and massively increasing the chances of early diagnosis of disorders. There has been a rapid development of human pose estimation methods in computer vision, thanks to advances in deep learning and machine learning. However, these methods are trained on datasets that feature adults in different contexts.
View Article and Find Full Text PDFMAGMA
September 2025
Computational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Heidelberglaan 100, 3585CX, Utrecht, The Netherlands.
Objective: Within gradient-spoiled transient-state MR sequences like Magnetic Resonance Fingerprinting or Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT), it is examined whether an optimized RF phase modulation can help to improve the precision of the resulting relaxometry maps.
Methods: Using a Cramer-Rao based method called BLAKJac, optimized sequences of RF pulses have been generated for two scenarios (amplitude-only modulation and amplitude + phase modulation) and for several conditions. These sequences have been tested on a phantom, a healthy human brain and a healthy human leg, to reconstruct parametric maps ( and ) as well as their standard deviations.
MAGMA
September 2025
Department of Medical Imaging, (766), Radboud University Medical Center, Geert Grooteplein 10Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, the Netherlands.
Objective: To improve B field homogeneity in prostate MR imaging and spectroscopy using a custom-designed 16-channel external local shim coil array.
Methods: In vivo prostate imaging was performed in seven healthy volunteers (mean age: 40.7 years) without bowel preparation.
Clin Transl Oncol
September 2025
Department of Radiation Oncology, Vithas La Milagrosa University Hospital, Madrid, 28010, Spain.
This narrative review analyzes current evidence comparing single-session and two-session approaches in Stereotactic Body Radiation Therapy (SBRT) and high-dose-rate (HDR) brachytherapy for localized prostate cancer. These ultra-hypofractionated strategies deliver high-precision ablative doses while minimizing exposure to normal tissues. SBRT regimens with fewer than five fractions show tumor control comparable to conventional treatments, offering reduced treatment burden and increased convenience.
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