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Objectives: The present study tests the effectiveness of entheseal robusticity (ER) as a potential predictor of adult age-at-death by applying multiple regression models to a large contemporary identified skeletal sample.
Materials And Methods: ER was recorded for 23 bilateral postcranial entheses on 481 adult individuals (271 females and 210 males) from the Frassetto identified skeletal collection of Sassari (Italy), following the method of Mariotti et al. 2007. ER scores were used as predictors in multiple regression analyses with age as the dependent variable; the performance of the resulting models was tested through standard error of estimate, the correlation coefficient between predicted and documented age, and the percentage of correctly classified individuals.
Results: ER show a higher correlation with age in females, resulting in more accurate estimates when compared with those obtained for males. Age-at-death is overestimated for male individuals under 45 years old and underestimated for older individuals. Regression models including a reduced set of ER sites result in better estimates compared with those using the complete set of variables.
Discussion: Results suggest the potential usefulness of ER for the estimation of age, especially for female skeletal remains. If used with caution, ER may be a valid complement to existing methods for the reconstruction of the biological profile of skeletal remains of archaeological and forensic interest.
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http://dx.doi.org/10.1002/ajpa.24083 | DOI Listing |
Diabetes Ther
September 2025
Diabetes Care Unit, Caen University Hospital, UNICAEN, 14033, Caen Cedex 09, France.
Introduction: Diabetes represents an increasing public health challenge in France, yet national data distinguishing type 1 from type 2 diabetes and insulin use remain limited. This study aimed to describe trends in the epidemiology, care pathways and health outcomes of adult individuals living with type 1 or type 2 diabetes in France from 2010 to 2019. It focused on individuals treated or not with insulin and applied a predictive classification algorithm to accurately distinguish between diabetes types using real-world data.
View Article and Find Full Text PDFAm J Biol Anthropol
September 2025
G. I. Tarha. Departmento de Ciencias Históricas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Objectives: This study evaluated the influence of genetic diversity, subsistence strategies, age at death, and their interplay on the prevalence of linear enamel hypoplasias (LEHs) in the indigenous populations of the Canary Islands. Additionally, we test the predictive adaptive hypothesis and the plasticity/constraint hypothesis within this unique archeological context.
Methods: LEH incidence, age of occurrence, and the number of stress episodes were assessed macroscopically in a sample of 409 individuals from six of the seven islands comprising the Canarian archipelago during the pre-contact or Indigenous period (2nd-15th century cal CE).
Neurology
September 2025
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.
Background And Objectives: Cerebral amyloid angiopathy (CAA) is the accumulation of β-amyloid (Aβ) in the walls of small vessels in the leptomeninges and cortex and is a risk factor of intracerebral hemorrhage and dementia, but its underlying mechanism is unknown. We examined cortical proteins in relation to CAA to elucidate the molecular mechanisms underlying CAA.
Methods: Data were collected from participants of 5 community-based cohorts of older adults.
Forensic Sci Int
August 2025
Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, United States.
The increasing number of forensic cases and solitary deaths ("kodokushi") involving older adults warrants targeted methods to serve this growing and vulnerable group. However, age-at-death estimation past midlife remains challenging due to diminished accuracy of traditional macroscopic age markers, often resulting in a single categorization of older age groups as "50 + ." This study evaluates the utility of cortical bone speed of sound (SoS), measured by quantitative ultrasound (QUS), as an alternative biomarker to quantify age-related changes in cortical bone quality and to estimate age-at-death in older adult skeletons.
View Article and Find Full Text PDFRev Inst Med Trop Sao Paulo
August 2025
Universidade Federal do Ceará, Programa de Pós-Graduação em Saúde Pública, Fortaleza, Ceará, Brazil.
Guaramiranga, Ceara State, Brazil, a tourist city 105.5 km from the capital Fortaleza, was a pilot site for vaccinating 100% of its 4,002 adult population with the first dose against COVID-19. The city received 3,328 CoronaVac, 1,685 AstraZeneca, and 174 Pfizer-BioNTech doses (5,187 in total).
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