98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.orglett.0c01958 | DOI Listing |
Appl Radiat Isot
August 2025
Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States. Electronic address:
We report a reliable fully automated procedure to produce a promising F-18 labeled sphingosine-1-phosphate receptor 1 (S1PR1) PET ligand, 3-((2-fluoro-4-(5-(4-(2-(fluoro-F)ethoxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzyl) (methyl)amino)propan-1-ol ([F]FZTA) on the GE TRACERlab FX2N module, using a one-pot two-step procedure following current Good Manufacturing Practices (cGMP). The MOM-protected precursor 1 was fluorinated with no-carrier-added [F]KF, catalyzed by Kryptofix 222 under heat, to afford the intermediate [F]2. After deprotecting the MOM-group on [F]2 under acidic condition, the reaction was quenched into a neutralized solution, which was then loaded on semi-preparative HPLC for purification.
View Article and Find Full Text PDFAntimicrobial resistance is a major global health threat, with disproportionate impact in regions with limited diagnostic infrastructure. To address this challenge, we developed BADLOCK (Bacterial and AMR Detection by SHERLOCK), a rapid, low-cost molecular diagnostic platform for direct detection of bacterial pathogens and resistance genes from clinical samples. BADLOCK operates as a one-pot CRISPR-Cas13a reaction capable of detecting nine bacterial species and four major resistance genes directly from positive blood culture.
View Article and Find Full Text PDFChem Commun (Camb)
August 2025
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
Correction for 'Sustainable and scalable one-pot synthesis of diaryliodonium salts' by Sayad Doobary , , 2025, , 5158-5161, https://doi.org/10.1039/D5CC00774G.
View Article and Find Full Text PDFACS Omega
May 2025
Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, London WC2R 2LS, U.K.
4-[F]-Fluorophenylglyoxal ([F]-FPG) is a novel arginine selective bioconjugation reagent for native protein F-labeling. Here, we report the automated radiosynthesis of [F]-FPG on a Scintomics GRP module. The radiochemical preparation was performed in a one-pot, two-step process using a DMSO-resistant cassette system.
View Article and Find Full Text PDFMolecules
April 2025
Institut für Organische Chemie und Makromolekulare Chemie, Mathematisch-Naturwissenschaftliche Fakultät, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany.
In the original publication [...
View Article and Find Full Text PDF